Protein Info for EX28DRAFT_3698 in Enterobacter asburiae PDN3

Annotation: guanosine monophosphate reductase, eukaryotic

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01305: guanosine monophosphate reductase
  • amino acids 2 to 344 (343 residues), 690 bits, E=2.6e-212
• PF00478: IMPDH
  • amino acids 9 to 338 (330 residues), 263.4 bits, E=1.5e-82

Best Hits

Swiss-Prot: 95% identical to GUAC_ENT38: GMP reductase (guaC) from Enterobacter sp. (strain 638)

KEGG orthology group: K00364, GMP reductase [EC: 1.7.1.7] (inferred from 98% identity to enc:ECL_00901)

MetaCyc: 93% identical to GMP reductase (Escherichia coli K-12 substr. MG1655)
GMP reductase. [EC: 1.7.1.7]

Predicted SEED Role

"GMP reductase (EC 1.7.1.7)" in subsystem Purine conversions (EC 1.7.1.7)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.7.1.7

Protein Sequence (347 amino acids)

>EX28DRAFT_3698 guanosine monophosphate reductase, eukaryotic (Enterobacter asburiae PDN3)
MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELERQFTFKHSGQTWSGVPIIAANMDTVGTF
EMATALAQFDILTAVHKHYSPEEWNAFVASASADVVRHVMVSTGTSDADFEKTKQILNAN
PALNFVCIDVANGYSEHFVQFVSKAREAWPTKTIIAGNVVTGEMCEELILSGADIVKVGI
GPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIISDGGCTTPGDVAKAFGGGADFVM
LGGMLAGHEESGGTVVEENGEKFMLFYGMSSESAMTRHVGGVAKYRAAEGKTVKLPLRGP
VEYTARDILGGLRSACTYVGASRLKELTKRTTFIRVQEQENRVFNSL