Protein Info for EX28DRAFT_3697 in Enterobacter asburiae PDN3

Annotation: dephospho-CoA kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01121: CoaE
  • amino acids 3 to 177 (175 residues), 237.4 bits, E=4.5e-75
• TIGR00152: dephospho-CoA kinase
  • amino acids 4 to 190 (187 residues), 217.4 bits, E=7.4e-69

Best Hits

Swiss-Prot: 77% identical to COAE_SHIFL: Dephospho-CoA kinase (coaE) from Shigella flexneri

KEGG orthology group: K00859, dephospho-CoA kinase [EC: 2.7.1.24] (inferred from 92% identity to enc:ECL_00900)

MetaCyc: 77% identical to dephospho-CoA kinase (Escherichia coli K-12 substr. MG1655)
Dephospho-CoA kinase. [EC: 2.7.1.24]

Predicted SEED Role

"Dephospho-CoA kinase (EC 2.7.1.24)" in subsystem Coenzyme A Biosynthesis (EC 2.7.1.24)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis I (bacteria) (9/9 steps found)
• superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
• coenzyme A biosynthesis I (bacteria) (4/4 steps found)
• coenzyme A biosynthesis II (eukaryotic) (4/4 steps found)

KEGG Metabolic Maps

• Pantothenate and CoA biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.24

Protein Sequence (206 amino acids)

>EX28DRAFT_3697 dephospho-CoA kinase (Enterobacter asburiae PDN3)
MGYIVALTGGIGSGKSTVADAFSRLGITIIDADIIARQVVEPNTPALKVIAEHFGQAVIN
ADGTLNRRQLRECIFSDSAEKVWLNALLHPIIHQETQRQIAAARSPYVLWVVPLLVENQL
HMKADRVLVIDVSPETQIQRTMTRDRVSREHAEQILAAQATRAQRLAVADDVIDNNGAPD
AIASDVARLHAQYLTFAAQAVAQEKP