Protein Info for EX28DRAFT_3150 in Enterobacter asburiae PDN3

Annotation: Transcriptional regulator, contains sigma factor-related N-terminal domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 322 PF04198: Sugar-bind" amino acids 71 to 320 (250 residues), 225.7 bits, see alignment E=2.8e-71

Best Hits

Swiss-Prot: 95% identical to LSRR_ENT38: Transcriptional regulator LsrR (lsrR) from Enterobacter sp. (strain 638)

KEGG orthology group: K11531, lsr operon transcriptional repressor (inferred from 99% identity to enc:ECL_04483)

Predicted SEED Role

"LsrR, transcriptional repressor of lsr operon" in subsystem Autoinducer 2 (AI-2) transport and processing (lsrACDBFGE operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (322 amino acids)

>EX28DRAFT_3150 Transcriptional regulator, contains sigma factor-related N-terminal domain (Enterobacter asburiae PDN3)
MSDKRTAEEGRFAGLALAEEELVARVAWCYYHDGLTQNDIGERLGLPRLKISRLLEKGRQ
SGVIRVQINSRYEGCLALETELQQRFGLKLVRVMPALNTPPMNVRLGIGAAQSLMGVLEP
GQLLAVGFGETTMSSLQHLSGFISSQQIRLVTLSGGVGPYMTGIGQLDAACSVSMIPAPL
RVSSAEVAGILKRETSVRDVILAATAADVAVVGIGSVNQRRDATILRSGYISEGEQLMYA
RKGAVGDILGYFLNAEGECVEELEIHKELLGVTLDELAQLPTIVGVAGGEEKADAIYAAL
KGRRINGLVTEETTARAVLALT