Protein Info for EX28DRAFT_2960 in Enterobacter asburiae PDN3

Annotation: Xaa-Pro aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 439 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details PF05195: AMP_N" amino acids 8 to 126 (119 residues), 122.3 bits, see alignment E=9.8e-40 PF00557: Peptidase_M24" amino acids 183 to 413 (231 residues), 231.6 bits, see alignment E=8.6e-73

Best Hits

Swiss-Prot: 87% identical to AMPP_ECOLI: Xaa-Pro aminopeptidase (pepP) from Escherichia coli (strain K12)

KEGG orthology group: K01262, Xaa-Pro aminopeptidase [EC: 3.4.11.9] (inferred from 95% identity to enc:ECL_04235)

MetaCyc: 87% identical to Xaa-Pro aminopeptidase (Escherichia coli K-12 substr. MG1655)
Xaa-Pro aminopeptidase. [EC: 3.4.11.9]

Predicted SEED Role

"Xaa-Pro aminopeptidase (EC 3.4.11.9)" (EC 3.4.11.9)

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.9

Use Curated BLAST to search for 3.4.11.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (439 amino acids)

>EX28DRAFT_2960 Xaa-Pro aminopeptidase (Enterobacter asburiae PDN3)
MVISSQEYSRRRQALLATMHPGSAALIFAAPEVTRSADSEYPYRQSSDFWYFTGFNEPEA
VLVLIKSNDTHNHSVIFNRVRDLTAEIWFGRRLGQEAAPAKLGVDRALAFSEINQQLYQL
LNGLDVLYHAQGEYAYADEIVFTALDKLRKGSRQNLSAPATLTDWRPVVHEMRLFKSEEE
LNLMRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHEFNRHGARYPSYNTIVGGGENGC
ILHYTENESALRDGDLVLIDAGCEYQGYAGDITRTFPVNGKFSPAQRAIYDIVLDSLETA
LRLYRPGTSMQEVTGEVVRIMITGLVKLGILKGDVDTLIAENAHRPYFMHGLSHWLGLDV
HDVGAYGTDRSRVLEPGMVLTVEPGLYIAPDADVPEEYRGIGIRIEDDIVITETGNENLT
ASVVKNADDIEALMAAARA