Protein Info for EX28DRAFT_2916 in Enterobacter asburiae PDN3

Annotation: diaminopimelate decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01048: diaminopimelate decarboxylase
  • amino acids 7 to 418 (412 residues), 462.6 bits, E=4.6e-143
• PF00278: Orn_DAP_Arg_deC
  • amino acids 30 to 376 (347 residues), 88.7 bits, E=2.4e-29
• PF02784: Orn_Arg_deC_N
  • amino acids 33 to 275 (243 residues), 204.8 bits, E=1.5e-64

Best Hits

Swiss-Prot: 86% identical to DCDA_ECOLI: Diaminopimelate decarboxylase (lysA) from Escherichia coli (strain K12)

KEGG orthology group: K01586, diaminopimelate decarboxylase [EC: 4.1.1.20] (inferred from 96% identity to enc:ECL_04165)

MetaCyc: 86% identical to diaminopimelate decarboxylase (Escherichia coli K-12 substr. MG1655)
Diaminopimelate decarboxylase. [EC: 4.1.1.20]

Predicted SEED Role

"Diaminopimelate decarboxylase (EC 4.1.1.20)" in subsystem Lysine Biosynthesis DAP Pathway (EC 4.1.1.20)

MetaCyc Pathways

• aspartate superpathway (24/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• L-lysine biosynthesis III (6/7 steps found)
• L-lysine biosynthesis VI (6/7 steps found)
• L-lysine biosynthesis II (6/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.20

Protein Sequence (420 amino acids)

>EX28DRAFT_2916 diaminopimelate decarboxylase (Enterobacter asburiae PDN3)
MPRPLNQTDTDLNADNLLRLPAEFGCPVWVYDAQIVREKIAALHQFDVVRFAQKACSNIH
ILRLMREQGVKVDSVSLGEIERALVAGFDPKADGDAIVFTADVIDDATLARVHELQIPVN
AGSVDMLEQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGENSKHGIWYADMPAALEVLQR
YGLKLVGIHMHIGSGVDYGHLEQVCGAMVRQVIDFGQDLEAISAGGGLSIPYREGEEAID
TDHYYGLWSAARDQIAAHLGHAVKLEIEPGRFLVAEAGVLVSQVRSVKEMGSRHFVLIDA
GFNDLMRPSMYGSYHHITALAADGRDLTQAPRVETVVAGPLCESGDVFTQQEGGKVETRA
LPEVKPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNGKARLIRRRQTIQELLALELI