Protein Info for EX28DRAFT_2798 in Enterobacter asburiae PDN3

Annotation: Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 504 PF01590: GAF" amino acids 22 to 154 (133 residues), 52.6 bits, see alignment E=3e-17 PF13185: GAF_2" amino acids 24 to 155 (132 residues), 30.9 bits, see alignment E=1.1e-10 PF00158: Sigma54_activat" amino acids 187 to 353 (167 residues), 229.2 bits, see alignment E=9.9e-72 PF14532: Sigma54_activ_2" amino acids 188 to 358 (171 residues), 73.8 bits, see alignment E=7.3e-24 PF01078: Mg_chelatase" amino acids 193 to 328 (136 residues), 25.2 bits, see alignment E=3.9e-09 PF07728: AAA_5" amino acids 210 to 329 (120 residues), 26.4 bits, see alignment E=2.4e-09 PF00004: AAA" amino acids 211 to 336 (126 residues), 22.2 bits, see alignment E=6.9e-08 PF25601: AAA_lid_14" amino acids 359 to 420 (62 residues), 56.4 bits, see alignment E=8.6e-19

Best Hits

Swiss-Prot: 94% identical to NORR_ENT38: Anaerobic nitric oxide reductase transcription regulator NorR (norR) from Enterobacter sp. (strain 638)

KEGG orthology group: K12266, anaerobic nitric oxide reductase transcription regulator (inferred from 94% identity to enc:ECL_04046)

Predicted SEED Role

"Functional role page for Anaerobic nitric oxide reductase transcription regulator NorR" in subsystem Nitrosative stress

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (504 amino acids)

>EX28DRAFT_2798 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains (Enterobacter asburiae PDN3)
MSFSVDVLAKIAIELQTGIGHQDRFQRLISTLRHVLECDASALLRYEGRQFIPLAIDGLA
KDVLGRRFTLEGHPRLETIARAGDVVRFPADSDLPDPYDGLIPGQESLKVHACIGLPLFA
GQNLIGALTLDGLSPDQFDTFSDEELRLIAALAAGALNNALLIEQLESQNILPGSPAAFE
QVTHTEMIGLSPGMAQLKKEIEIVAASDLNVLIFGETGTGKELVAKSIHEASPRAVNPLV
YLNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLSLQAKLL
RVLQYGDIQRVGDDRSHRVDVRVLAATNRDLREAVLAGQFRADLFHRLSVFPLTVPPLRD
RGDDVLLLAGFFCEQCRLRMGLSRVVLSPGARSHLLSYGWPGNVRELEHAIHRAVVLARA
TRSGDEVVIHARHFALQDETAPAIAQVVPEITNENLREATEAFQRQMITRALEQNNRSWA
ACARALEMDVANLHRLAKRLGLKG