Protein Info for EX28DRAFT_2664 in Enterobacter asburiae PDN3

Annotation: NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 447 PF05896: NQRA" amino acids 1 to 257 (257 residues), 375.4 bits, see alignment E=2.3e-116 TIGR01936: NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit" amino acids 3 to 447 (445 residues), 606.7 bits, see alignment E=1.3e-186 PF11973: NQRA_SLBB" amino acids 262 to 310 (49 residues), 65.8 bits, see alignment 6.2e-22

Best Hits

Swiss-Prot: 77% identical to NQRA_KLEP7: Na(+)-translocating NADH-quinone reductase subunit A (nqrA) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K00346, Na+-transporting NADH:ubiquinone oxidoreductase subunit A [EC: 1.6.5.-] (inferred from 89% identity to enc:ECL_01057)

Predicted SEED Role

"Na(+)-translocating NADH-quinone reductase subunit A (EC 1.6.5.-)" in subsystem Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes (EC 1.6.5.-)

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.-

Use Curated BLAST to search for 1.6.5.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (447 amino acids)

>EX28DRAFT_2664 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit (Enterobacter asburiae PDN3)
MFKIKKGLDLPIAGVPAQHVSTGASVRHVAILGEDYLGMRPSMLVQEGDRVIKGQALFED
KKNPGVMFTAPASGTVVAINRGERRVLQSVVIRTEGDDKREFAHYDTAELASLNRDAVQD
QLLASGLWTALRTRPFSKTPVPGTEPAAIFVTAIDTNPLSVDPEPVILAQRKAFDAGLTI
LTRLTPGKVHVCQAGGGKLGGHPLGQVTFNEFSGPHPAGLVGTHIHFLEPVSLTKQVWHL
NYQDVIAIGKLFTTGELCAERIIAIGGPQAANPRLVKTLLGADINELLVGETKEGENRLI
SGSVLSGRHAANAHAYLGRFHLQVSIVQEGREKELFGWVLPGAEKYSVTRTTLGHFLRKK
LFSFSTSTHGGERAMVPIGNYERVMPLDILPTVLLRDLLAGDTDGAQALGCLELDEEDLA
LCTYVCPGKYEYGPVLREVLTRIEQEG