Protein Info for EX28DRAFT_2418 in Enterobacter asburiae PDN3

Annotation: The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1051 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 341 to 360 (20 residues), see Phobius details amino acids 367 to 388 (22 residues), see Phobius details amino acids 394 to 417 (24 residues), see Phobius details amino acids 438 to 460 (23 residues), see Phobius details amino acids 470 to 496 (27 residues), see Phobius details amino acids 534 to 552 (19 residues), see Phobius details amino acids 864 to 881 (18 residues), see Phobius details amino acids 890 to 910 (21 residues), see Phobius details amino acids 916 to 940 (25 residues), see Phobius details amino acids 964 to 985 (22 residues), see Phobius details amino acids 995 to 1019 (25 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1028 (1028 residues), 1087.5 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1020 (1020 residues), 1047.3 bits, see alignment E=0 PF03176: MMPL" amino acids 336 to 500 (165 residues), 24.9 bits, see alignment E=9.8e-10 amino acids 859 to 1023 (165 residues), 24.6 bits, see alignment E=1.1e-09

Best Hits

KEGG orthology group: None (inferred from 95% identity to enc:ECL_03149)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1051 amino acids)

>EX28DRAFT_2418 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family (Enterobacter asburiae PDN3)
MLTFFIKRPRFAMVIALVITLVGAIALRIIPVEQYPQIAPPVVNVSASWPGASSTDVAEA
IATPLETQLNGVDHMLYMESTSSDEGTYSLNITFAAGTDPDLAAIDVQNRVAQAVAQLPT
EAQQNGVQVRKRATNLMMGVSLYSPNNTHTPLFVSNYASTQVREALSRLPGVGQVQMFGA
RDYSMRIWLRPDRMNALNVTTDDVAQALREQNVQGAAGQVGTPPVFNGQQQTLTINGLGR
LSQAEDFADIIIRAGEMGQLVRLKDVATIELGSRSYSSGARLNGHDSAYLGIYPTPSANA
LRVADAVRAELERLSTRFPDDLVYEVKFDTTSFVAATIKEIGVSLALTLLAVVVVVSLFL
QSWRATLIVALAIPVSLVGTFAVLYTLGYSANTLSLFAIILALTMVVDDAIVVVESVETL
MAEGQSRTAATALALRQIAGPVIATTLVLLAVFVPVALLPGIVGELYRQFAVTLSTAVTL
SSLVALTLTPALCAMLLRPRPEKPAAVYRAFNRGMDATRGFYTRIVHVLNLRPWLALLAT
AGAAAVVAFSFTSMPKSFLPQEDQGYFFASVQLPEAASLERTEAVMNTARELIAKNPAVE
DVIQVSGFNILNGTSASNGGFISIMLKDWSERPPLDEVMGTLQRQLLALPEATIMTFAPP
TLPGLGNASGFDLRIQAQAGQSPAELERVTREVLAKANQHPQLSRVFTTWSSNVPQLTLT
VDRERAARLDVPVSRIFSSLQTAFGGTRAGDFSVNNRVYHVVMQNEMQWRERAEQISELF
VRSNSGERVRLSNLVTITPSVGAPFLQQYNQFPSVSVSGSAAAGVSSSTAMAAMGEILAE
NLPAGYDYAWSGMSYQEQQTGNQAIWIVLAAVVMAWLFLVAQYESWTLPASVMLSVLFAI
GGALVWLWMAGYANDVYVQIGLVLLIALAAKNAILIVEFARARRMDGMAIVDAAREGASR
RFRAVMMTAVSFIIGVLPMMLATGAGAQSRRIIGTTVFSGMLVATVVGILFIPALFVLFQ
RLREWGHRLTDSSPTARSASEPEKSASRRRR