Protein Info for EX28DRAFT_2298 in Enterobacter asburiae PDN3

Annotation: N-acetylglucosamine-6-phosphate deacetylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00221: N-acetylglucosamine-6-phosphate deacetylase
  • amino acids 1 to 377 (377 residues), 589 bits, E=2e-181
• PF01979: Amidohydro_1
  • amino acids 50 to 379 (330 residues), 161.6 bits, E=1.6e-51

Best Hits

Swiss-Prot: 89% identical to NAGA_ECOLI: N-acetylglucosamine-6-phosphate deacetylase (nagA) from Escherichia coli (strain K12)

KEGG orthology group: K01443, N-acetylglucosamine-6-phosphate deacetylase [EC: 3.5.1.25] (inferred from 98% identity to enc:ECL_03038)

MetaCyc: 89% identical to N-acetylglucosamine-6-phosphate deacetylase (Escherichia coli K-12 substr. MG1655)
N-acetylglucosamine-6-phosphate deacetylase. [EC: 3.5.1.25]

Predicted SEED Role

"N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)" in subsystem Chitin and N-acetylglucosamine utilization or Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 3.5.1.25)

MetaCyc Pathways

• peptidoglycan recycling I (14/14 steps found)
• superpathway of N-acetylneuraminate degradation (19/22 steps found)
• D-galactosamine and N-acetyl-D-galactosamine degradation (4/4 steps found)
• N-acetylglucosamine degradation II (3/3 steps found)
• N-acetylglucosamine degradation I (2/2 steps found)
• N-acetyl-D-galactosamine degradation (4/5 steps found)
• superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation (3/6 steps found)
• chitin derivatives degradation (4/8 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Galactose metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.25

Use Curated BLAST to search for 3.5.1.25

Protein Sequence (382 amino acids)

>EX28DRAFT_2298 N-acetylglucosamine-6-phosphate deacetylase (Enterobacter asburiae PDN3)
MYALTHGRIYTGHEILDDHAIVIADGLIERVCPLAELPPEIEHRSLNGAVISPGFIDVQL
NGCGGVQFNDTADAVTVETLEIMQKANEKSGCTSYLPTLITSSDDLMKQGIRVMREYLAK
HPNQALGLHLEGPWLNMVKKGTHNPNYVRKPDAELVDYMCANADVITKVTLAPEMTGTDV
ISKLAGAGIIVSAGHSNATLKEAKAGFRAGITFATHLYNAMPYITGREPGLVGAILDEPD
VYCGIIADGLHVDYTNIRNAKRLKGDKLCLVTDATAPAGANIEQFIFAGKTIYYRNGLCV
DENGTLSGSSLTMIEGVRNLVEHCGIALDEVLRMATLYPARAMGVDKQLGGIAPGMVANL
TAFTHDYKIIKTIVNGNEVVTE