Protein Info for EX28DRAFT_2285 in Enterobacter asburiae PDN3
Annotation: ornithine decarboxylase SpeF
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 86% identical to DCOS_ECOLI: Inducible ornithine decarboxylase (speF) from Escherichia coli (strain K12)
KEGG orthology group: K01581, ornithine decarboxylase [EC: 4.1.1.17] (inferred from 95% identity to enc:ECL_03025)MetaCyc: 86% identical to inducible ornithine decarboxylase (Escherichia coli K-12 substr. MG1655)
Ornithine decarboxylase. [EC: 4.1.1.17]
Predicted SEED Role
"Ornithine decarboxylase (EC 4.1.1.17)" in subsystem Arginine and Ornithine Degradation or Polyamine Metabolism (EC 4.1.1.17)
MetaCyc Pathways
- superpathway of arginine and polyamine biosynthesis (16/17 steps found)
- superpathway of L-arginine and L-ornithine degradation (12/13 steps found)
- superpathway of ornithine degradation (8/8 steps found)
- superpathway of polyamine biosynthesis I (7/8 steps found)
- superpathway of putrescine biosynthesis (3/4 steps found)
- putrescine biosynthesis III (1/2 steps found)
- superpathway of polyamine biosynthesis II (4/8 steps found)
- superpathway of hyoscyamine (atropine) and scopolamine biosynthesis (3/16 steps found)
KEGG Metabolic Maps
- Arginine and proline metabolism
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Glutathione metabolism
- Urea cycle and metabolism of amino groups
Isozymes
Compare fitness of predicted isozymes for: 4.1.1.17
Use Curated BLAST to search for 4.1.1.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (732 amino acids)
>EX28DRAFT_2285 ornithine decarboxylase SpeF (Enterobacter asburiae PDN3) MKSLKIAASRACPDCFTTQRELVDVRASDYIDVAAIVLAVTDIASGILDEIEATGFGIPV FVATHKEEFIPADYLSRIHGVFEYSDTSNDFYGRQLEAAAQKYETQLRPPFFRALVDYVK QGNSAFDCPGHQGGQFFRRHPAGNQFVDFFGETLFRSDLCNADVAMGDLLIHEGAPCIAQ QHAAKVFNADKTYFVLNGTSSSNKVVLNALLTPGDLVLFDRNNHKSNHHGALLQAGATPV YLETARNPYGFIGGIDAHCFEESYLRELVAEVAPGRARDARPFRLAVIQLGTYDGTIYNA RQVVDKIGHLCDYILFDSAWVGYEQFIPMMADCSPLLLELNENDPGILVTQSVHKQQAGF SQTSQIHKKDSHIKGQQRYVPHKRLNNAFMMHASTSPFYPLFAALDINARMHEGQSGRNM WMDCVVNGIEARKLILENCRYLRPFVPETVDGRPWESWDTAEIATDLRFFHFVPGENWHA FEGYAEHQYFIDPCKLLLTTPGINARTGEYDDFGVPATILANFLRENGIVPEKCDLNSIL FLLTPAEDMGKLQQLVAQLVRFEKLLESDVPLKDVLPSLYKQHPERYADYTLRQICQEMH DLYARHNVKQLQKEMFRKSHFPRVMMNPQDANYAYLRGEVELVSLRDAEGRIAAEGALPY PPGVLCVVPGEVWGGSVLRYFAALEEGINLLPGFAPELQGVYVEECEGRKQVRCNVIKQP AAQPALLKGEKL