Protein Info for EX28DRAFT_2063 in Enterobacter asburiae PDN3

Annotation: L-threonine aldolase (EC 4.1.2.5)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 333 PF01212: Beta_elim_lyase" amino acids 3 to 282 (280 residues), 360.3 bits, see alignment E=7.5e-112 PF00155: Aminotran_1_2" amino acids 21 to 309 (289 residues), 36.1 bits, see alignment E=4.5e-13

Best Hits

Swiss-Prot: 88% identical to LTAE_ECOLI: Low specificity L-threonine aldolase (ltaE) from Escherichia coli (strain K12)

KEGG orthology group: K01620, threonine aldolase [EC: 4.1.2.5] (inferred from 97% identity to ent:Ent638_1386)

MetaCyc: 88% identical to low-specificity L-threonine aldolase (Escherichia coli K-12 substr. MG1655)
Threonine aldolase. [EC: 4.1.2.48, 4.1.2.5]; LTAA-RXN [EC: 4.1.2.48, 4.1.2.5, 4.1.2.49]; 4.1.2.48 [EC: 4.1.2.48, 4.1.2.5, 4.1.2.49]; Phenylserine aldolase. [EC: 4.1.2.48, 4.1.2.5, 4.1.2.49, 4.1.2.26]

Predicted SEED Role

"Low-specificity L-threonine aldolase (EC 4.1.2.48)" (EC 4.1.2.48)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.26 or 4.1.2.48 or 4.1.2.49 or 4.1.2.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (333 amino acids)

>EX28DRAFT_2063 L-threonine aldolase (EC 4.1.2.5) (Enterobacter asburiae PDN3)
MIDLRSDTVTRPSRAMLEEMMAAPVGDDVYGDDPTVNELQRYAAELSGKEAALFLPTGTQ
ANLVALLSHCERGEEYIVGQGAHNYLYEAGGAAVLGSIQPQPIDAAPDGSLPLDKVAAKI
KADDIHFARTRLLSLENTHNGKVLPREYLKAAWEFTRERGLGLHVDGARIFNAIVEYGCE
LKEIAQYCDSFTICLSKGLGTPVGSLLVGNADYIKRANRWRKMTGGGMRQAGILAAAGLY
ALKNNVARLKDDHDNAAWMATQLREIGADVMRHDTNMLFVRVGDDRAAALGEFMKSRGVL
INASPVVRLVMHLDVSREQLADVVKHWQAFLQR