Protein Info for EX28DRAFT_1908 in Enterobacter asburiae PDN3

Annotation: Nucleoside permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 394 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 32 to 57 (26 residues), see Phobius details amino acids 87 to 108 (22 residues), see Phobius details amino acids 166 to 187 (22 residues), see Phobius details amino acids 193 to 213 (21 residues), see Phobius details amino acids 241 to 270 (30 residues), see Phobius details amino acids 281 to 313 (33 residues), see Phobius details amino acids 334 to 357 (24 residues), see Phobius details amino acids 373 to 393 (21 residues), see Phobius details PF01773: Nucleos_tra2_N" amino acids 10 to 82 (73 residues), 66.4 bits, see alignment E=4.1e-22 PF07670: Gate" amino acids 91 to 191 (101 residues), 54.4 bits, see alignment E=2.3e-18 PF07662: Nucleos_tra2_C" amino acids 194 to 391 (198 residues), 196.9 bits, see alignment E=5.2e-62

Best Hits

Swiss-Prot: 71% identical to NUPC_ECOL6: Nucleoside permease NupC (nupC) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K03317, concentrative nucleoside transporter, CNT family (inferred from 98% identity to enc:ECL_02616)

MetaCyc: 71% identical to nucleoside:H+ symporter NupC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-108A; TRANS-RXN-108B; TRANS-RXN-108C; TRANS-RXN-108D; TRANS-RXN-108E; TRANS-RXN-108F; TRANS-RXN-108G; TRANS-RXN-108H; TRANS-RXN-108I; TRANS-RXN-476

Predicted SEED Role

"Nucleoside permease NupC" in subsystem Deoxyribose and Deoxynucleoside Catabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (394 amino acids)

>EX28DRAFT_1908 Nucleoside permease (Enterobacter asburiae PDN3)
MFKIVHFLLALVIILALAWLVSFDRRKIRIRYVLQLIVIEIALAFFFLHAESGLFLIKYV
SGFFESLLKFASEGTNFVFGGMGEKGLAFIFLGVLCPIIFISALIGILQHWRILPIFIRV
IGTLLSKLNGMGKLESFNAVSSLILGQSENFIAYKGVLGDLSSRRLFTMAATAMSTVSLS
IVGAYMTMLDAKFVVAALILNMFSTFIILSVINPARPEAEPDIKLEKLHESQSFFEMLGE
YILAGFKVAMIILAMLIGFIALISAVNALFSSVFGMSFQQILGYVFYPLAWLVGIPLSDA
LNAGSIMATKLVANEFVAMIELQKIAHQMSPRGLGILSVFLVSFANFASIGIVAGAIKGL
NEQQGNVVSRFGLRLVYGATLVSLLSASFAGLVL