Protein Info for EX28DRAFT_1838 in Enterobacter asburiae PDN3

Annotation: 3-oxoacyl-(acyl-carrier-protein) synthase III

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 95% identical to FABH_ENT38: 3-oxoacyl-[acyl-carrier-protein] synthase 3 (fabH) from Enterobacter sp. (strain 638)

KEGG orthology group: K00648, 3-oxoacyl-[acyl-carrier-protein] synthase III [EC: 2.3.1.180] (inferred from 98% identity to enc:ECL_02545)

MetaCyc: 93% identical to 3-oxoacyl-[acyl carrier protein] synthase 3 (Escherichia coli K-12 substr. MG1655)
[Acyl-carrier-protein] S-acetyltransferase. [EC: 2.3.1.38]; Beta-ketoacyl-acyl-carrier-protein synthase III. [EC: 2.3.1.38, 2.3.1.180]

Predicted SEED Role

"3-oxoacyl-[acyl-carrier-protein] synthase, KASIII (EC 2.3.1.180)" (EC 2.3.1.180)

MetaCyc Pathways

superpathway of fatty acids biosynthesis (E. coli) (51/53 steps found)
superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
superpathway of fatty acid biosynthesis I (E. coli) (16/16 steps found)
superpathway of fatty acid biosynthesis initiation (5/5 steps found)
fatty acid biosynthesis initiation (type II) (3/3 steps found)
fatty acid biosynthesis initiation (mitochondria) (3/4 steps found)
streptorubin B biosynthesis (20/34 steps found)

KEGG Metabolic Maps

Fatty acid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.180 or 2.3.1.38

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (317 amino acids)

>EX28DRAFT_1838 3-oxoacyl-(acyl-carrier-protein) synthase III (Enterobacter asburiae PDN3)
MYTKILGTGSYLPKQVRTNADLEKMVDTSDEWIVTRTGIRERRIAAPDETVSTMGYEAAQ
RAIEMAGIDKEQIGLIVVATTSATHAFPSAACQVQNMLGIKGCPAFDVAAACAGFTYALS
VADQYVKSGAVKYALVIGADVLARTCDPTDRGTIIIFGDGAGAVLLGQSEEPGIISTHLH
ADGSYGELLTLPNADRVNPDNSIYLTMAGNEVFKVAVTELAHIVDETLEANNLERSALDW
LVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCAFDEAVRDGRIKRGQLVL
LEAFGGGFTWGSALVRF