Protein Info for EX28DRAFT_1801 in Enterobacter asburiae PDN3

Annotation: Signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 487 signal peptide" amino acids 13 to 17 (5 residues), see Phobius details transmembrane" amino acids 18 to 41 (24 residues), see Phobius details amino acids 192 to 217 (26 residues), see Phobius details PF08918: PhoQ_Sensor" amino acids 10 to 189 (180 residues), 283.9 bits, see alignment E=1.4e-88 PF00672: HAMP" amino acids 213 to 262 (50 residues), 22.9 bits, see alignment 2.2e-08 PF02518: HATPase_c" amino acids 377 to 477 (101 residues), 65.4 bits, see alignment E=1.6e-21 PF14501: HATPase_c_5" amino acids 377 to 464 (88 residues), 29.3 bits, see alignment E=1.7e-10

Best Hits

Swiss-Prot: 82% identical to PHOQ_SALCH: Virulence sensor histidine kinase PhoQ (phoQ) from Salmonella choleraesuis (strain SC-B67)

KEGG orthology group: K07637, two-component system, OmpR family, sensor histidine kinase PhoQ [EC: 2.7.13.3] (inferred from 95% identity to enc:ECL_02505)

MetaCyc: 82% identical to sensor histidine kinase PhoQ (Escherichia coli K-12 substr. MG1655)
Histidine kinase. [EC: 2.7.13.3]

Predicted SEED Role

"Sensor protein PhoQ (EC 2.7.13.3)" in subsystem Lipid A modifications (EC 2.7.13.3)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (487 amino acids)

>EX28DRAFT_1801 Signal transduction histidine kinase (Enterobacter asburiae PDN3)
MRRILRHILPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFY
TLAKWENNRITVEMPENLNQQSPTLALIYNEKGKLLWAQRDIPWLVKSIRPDWLKTNGFH
EIEADLNTTSSLIREDRSLQQKLNEIRADNAETEMTHSVAINLYPATLNMPQLTIVVIDT
IPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLN
PETTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSMRSSKLSV
DDAEPVMLEQISRISQQIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKG
VNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSARQTETELHIIVEDDGPG
IPRNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIFGRQ
QPTLNDS