Protein Info for EX28DRAFT_1618 in Enterobacter asburiae PDN3

Annotation: adenosine deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01430: adenosine deaminase
  • amino acids 6 to 330 (325 residues), 356.9 bits, E=4.6e-111
• PF00962: A_deaminase
  • amino acids 7 to 331 (325 residues), 414 bits, E=2.2e-128

Best Hits

Swiss-Prot: 94% identical to ADD_ENT38: Adenosine deaminase (add) from Enterobacter sp. (strain 638)

KEGG orthology group: K01488, adenosine deaminase [EC: 3.5.4.4] (inferred from 96% identity to enc:ECL_02300)

MetaCyc: 88% identical to adenosine deaminase (Escherichia coli K-12 substr. MG1655)
Adenosine deaminase. [EC: 3.5.4.4]; 3.5.4.4 [EC: 3.5.4.4]

Predicted SEED Role

"Adenosine deaminase (EC 3.5.4.4)" in subsystem Purine conversions (EC 3.5.4.4)

MetaCyc Pathways

• superpathway of purine deoxyribonucleosides degradation (7/7 steps found)
• purine ribonucleosides degradation (6/6 steps found)
• adenine and adenosine salvage III (4/4 steps found)
• purine deoxyribonucleosides degradation I (4/4 steps found)
• purine nucleotides degradation II (aerobic) (9/11 steps found)
• adenine and adenosine salvage V (3/3 steps found)
• purine deoxyribonucleosides degradation II (3/3 steps found)
• adenosine nucleotides degradation II (3/5 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.4.4

Protein Sequence (333 amino acids)

>EX28DRAFT_1618 adenosine deaminase (Enterobacter asburiae PDN3)
MIDTRLPLTDIHRHLDGNIRAQTILDLGRQFNLTLPAQTLESLIPHVQVTSSEPDLVSFL
SKLDWGVKMLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMTHSLPVAGVVEAVI
EGVREGCKTFDVQARLIGIMSRTFGEAACLQELEALLAHRDAITAVDLAGDELGFPGSLF
LSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRALMDFLAEQRI
GIESCLTSNIQTSTVATLAQHPLKTFLEHGVLASLNTDDPAVQGVDIIHEYNIAAPQAGL
SREQIRQAQINGLEIAFLTPEEKQALKDKVARG