Protein Info for EX28DRAFT_1374 in Enterobacter asburiae PDN3

Annotation: Short-chain dehydrogenases of various substrate specificities

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00106: adh_short
  • amino acids 2 to 180 (179 residues), 128.6 bits, E=6.6e-41
• PF08659: KR
  • amino acids 3 to 154 (152 residues), 30.3 bits, E=1.2e-10
• PF01370: Epimerase
  • amino acids 4 to 157 (154 residues), 43.2 bits, E=9.7e-15
• PF13460: NAD_binding_10
  • amino acids 8 to 173 (166 residues), 36.6 bits, E=1.4e-12
• PF13561: adh_short_C2
  • amino acids 8 to 180 (173 residues), 86.4 bits, E=7e-28

Best Hits

KEGG orthology group: None (inferred from 89% identity to enc:ECL_02105)

Predicted SEED Role

"Oxidoreductase, short-chain dehydrogenase/reductase family (EC 1.1.1.-)" (EC 1.1.1.-)

KEGG Metabolic Maps

• Alkaloid biosynthesis I
• Aminosugars metabolism
• Ascorbate and aldarate metabolism
• Benzoate degradation via CoA ligation
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of type II polyketide products
• Biosynthesis of unsaturated fatty acids
• Bisphenol A degradation
• Butanoate metabolism
• C21-Steroid hormone metabolism
• Fructose and mannose metabolism
• Glycine, serine and threonine metabolism
• Insect hormone biosynthesis
• Linoleic acid metabolism
• Nucleotide sugars metabolism
• Polyketide sugar unit biosynthesis
• Retinol metabolism
• Tetrachloroethene degradation

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.-

Use Curated BLAST to search for 1.1.1.-

Protein Sequence (239 amino acids)

>EX28DRAFT_1374 Short-chain dehydrogenases of various substrate specificities (Enterobacter asburiae PDN3)
MKTVLITGASSGIGAGLAKSFAADGYHVIACGRDPARLEALHQTCPNLTVRLFDMTDRDA
CRQALTGSYADLIILCAGTCEYLDGGVVDAALVERVMATNFLGPVNCLDALQPQLAAGNR
VVLVSSMAHWLPFPRAEAYGASKAALSWFAESLRLDWEPKGIAVTVVSPGFVDTPLTRKN
DFAMPGRVSVEEAVKAIRTGLAAGKMHIAFPDGFGFILRLLSGLPAFLQRALLRRMVRS