Protein Info for EX28DRAFT_1169 in Enterobacter asburiae PDN3

Annotation: heavy metal efflux pump, CzcA family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1046 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 340 to 358 (19 residues), see Phobius details amino acids 364 to 384 (21 residues), see Phobius details amino acids 390 to 411 (22 residues), see Phobius details amino acids 445 to 465 (21 residues), see Phobius details amino acids 485 to 505 (21 residues), see Phobius details amino acids 535 to 554 (20 residues), see Phobius details amino acids 874 to 891 (18 residues), see Phobius details amino acids 898 to 917 (20 residues), see Phobius details amino acids 928 to 948 (21 residues), see Phobius details amino acids 985 to 1004 (20 residues), see Phobius details amino acids 1012 to 1038 (27 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1045 (1045 residues), 1646.9 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1038 (1033 residues), 785.3 bits, see alignment E=8.7e-240

Best Hits

Swiss-Prot: 96% identical to SILA_SALTM: Putative cation efflux system protein SilA (silA) from Salmonella typhimurium

KEGG orthology group: K07787, Cu(I)/Ag(I) efflux system membrane protein CusA (inferred from 68% identity to adn:Alide_2726)

MetaCyc: 87% identical to copper/silver export system RND permease (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-90; TRANS-RXN0-280

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1046 amino acids)

>EX28DRAFT_1169 heavy metal efflux pump, CzcA family (Enterobacter asburiae PDN3)
MIEWIIRRSVANRFLVMMGALFLSVWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQI
VENQVTYPLTTTMLSVPGAKTVRGFSQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGK
LPAGVSSEIGPDATGVGWIFEYALVDRSGKHDLAELRSLQDWFLKFELKTIPNVAEVASV
GGVVKQYQIQVNPLKLAQYGISLPEVKQALESSNQEAGGSSVEMAEAEYMVRASGYLQTM
DDFNNIVLKTGENGVPIYLRDVARVQTGPEMRRGIAELNGQGEVAGGVVILRSGKNAREV
ITAVKDKLETLKASLPEGVEIVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHV
RSALVAIISLPLGLCIAFIVMHFQGMNANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEE
WDRQHPGEQIDNATRWKVITNASVEVGPALFISLLIITLSFIPVFTLEGQEGRLFGPLAF
TKTYSMAGAAALAIIVIPILMGFWIRGKIPAETSNPLNRLLIKAYHPLLIKVLHWPKTTL
LVAALSIFTVIWPLSQVGGEFLPKINEGDLLYMPSTLPGVSPAEAAALLQTTDKLIKTVP
EVASVFGKTGKAETATDSAPLEMVETTIQLKPENEWRPGMTIDKIIDELDKTVRLPGLAN
LWVPPIRNRIDMLSTGIKSPIGIKVSGTVLSDIDATAQSIEAVAKTVPGVVSALAERLEG
GRYIDVDINREKASRYGMTVGDVQLFVSSAIGGATVGETVEGVARYPINIRYPQDYRNSP
SALKQMPILTPMKQQITLGDVADINVVSGPTMLKTENARPASWIYIDARGRDMVSVVNDI
KTAISQNVKLRPGTSVSFSGQFELLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALLI
LMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVAAEFGVVMLMYLRHAVEAQPALSH
RDTFTEQGLDDALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGM
ITAPLLSLFIIPAVYKLIWLRRHKKP