Protein Info for EX28DRAFT_0557 in Enterobacter asburiae PDN3

Annotation: Antimicrobial peptide resistance and lipid A acylation protein PagP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 191 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF07017: PagP" amino acids 42 to 188 (147 residues), 199.4 bits, see alignment E=9.3e-64

Best Hits

Swiss-Prot: 91% identical to PAGP_ENTCL: Lipid A palmitoyltransferase PagP (pagP) from Enterobacter cloacae

KEGG orthology group: None (inferred from 87% identity to kva:Kvar_2130)

MetaCyc: 60% identical to Lipid A palmitoyltransferase (Escherichia coli K-12 substr. MG1655)
RXN-20913 [EC: 2.3.1.251]; 2.3.1.251 [EC: 2.3.1.251]; 2.3.1.251 [EC: 2.3.1.251]; 2.3.1.251 [EC: 2.3.1.251]; 2.3.1.251 [EC: 2.3.1.251]; 2.3.1.251 [EC: 2.3.1.251]

Predicted SEED Role

"Lipid A acylation protein PagP, palmitoyltransferase" in subsystem Lipid A modifications

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.251

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (191 amino acids)

>EX28DRAFT_0557 Antimicrobial peptide resistance and lipid A acylation protein PagP (Enterobacter asburiae PDN3)
MQRTFSAFWMVLFLFVAPLNAEPNVYSEQRISGWWNALTDDISQTWEEPQRYDLYLPFLS
WHARFMYDKEKTDNYNEMPWGGGLGVSRYNEEGNWSALFAMMFKDSHNEWQPAMGYGWEK
GWYLDNAKDFRLGLGAAAGITARDDFANYVPLPFIFPLFSAGYKRVTVQFTYIPGTYNNG
NVLFAWLRLGF