Protein Info for EX28DRAFT_0538 in Enterobacter asburiae PDN3

Annotation: histidinol-phosphate aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01141: histidinol-phosphate transaminase
  • amino acids 8 to 349 (342 residues), 417.3 bits, E=2.1e-129
• PF00155: Aminotran_1_2
  • amino acids 41 to 348 (308 residues), 250.2 bits, E=1.8e-78

Best Hits

Swiss-Prot: 93% identical to HIS8_ENT38: Histidinol-phosphate aminotransferase (hisC) from Enterobacter sp. (strain 638)

KEGG orthology group: K00817, histidinol-phosphate aminotransferase [EC: 2.6.1.9] (inferred from 97% identity to enc:ECL_03341)

MetaCyc: 87% identical to histidinol-phosphate aminotransferase (Escherichia coli K-12 substr. MG1655)
Histidinol-phosphate transaminase. [EC: 2.6.1.9]

Predicted SEED Role

"Histidinol-phosphate aminotransferase (EC 2.6.1.9)" in subsystem Histidine Biosynthesis (EC 2.6.1.9)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
• superpathway of chorismate metabolism (54/59 steps found)
• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• L-histidine biosynthesis (10/10 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• L-phenylalanine biosynthesis I (3/3 steps found)
• L-tyrosine biosynthesis I (3/3 steps found)
• 3-(4-hydroxyphenyl)pyruvate biosynthesis (1/1 steps found)
• L-phenylalanine degradation II (anaerobic) (2/3 steps found)
• L-tyrosine degradation II (1/2 steps found)
• atromentin biosynthesis (1/2 steps found)
• L-phenylalanine degradation III (2/4 steps found)
• L-tyrosine degradation III (2/4 steps found)
• L-tyrosine degradation IV (to 4-methylphenol) (1/3 steps found)
• L-phenylalanine degradation IV (mammalian, via side chain) (4/9 steps found)
• 4-hydroxybenzoate biosynthesis I (eukaryotes) (1/5 steps found)
• L-phenylalanine degradation VI (reductive Stickland reaction) (1/5 steps found)
• L-tyrosine degradation I (1/5 steps found)
• L-tyrosine degradation V (reductive Stickland reaction) (1/5 steps found)
• superpathway of plastoquinol biosynthesis (1/5 steps found)
• rosmarinic acid biosynthesis I (1/10 steps found)
• (S)-reticuline biosynthesis I (1/11 steps found)
• superpathway of rosmarinic acid biosynthesis (1/14 steps found)
• anaerobic aromatic compound degradation (Thauera aromatica) (3/27 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis II
• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of phenylpropanoids
• Histidine metabolism
• Novobiocin biosynthesis
• Phenylalanine metabolism
• Phenylalanine, tyrosine and tryptophan biosynthesis
• Tyrosine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.9

Protein Sequence (353 amino acids)

>EX28DRAFT_0538 histidinol-phosphate aminotransferase (Enterobacter asburiae PDN3)
MNIEELARENVRRLTPYQSARRLGGKGDVWLNANEFPTAVQFELSQQTLNRYPECQPKAV
IENYAQYAGVKPEQVLVSRGADEGIELLIRAFCEPGKDAVMYCQPTYGMYSVSAETFGVA
CRNVQALENWQLDLQGIADNLDGVKVVFVCSPNNPTGQIINPQDIRTLLEMTRGKALVVA
DEAYIEFCPQATLAGWLEEYPHLVVLRTLSKAFALAGLRCGFTLANKEVIDLLLKVIAPY
PLSTPVADIAAQALTPQGINAMRERVAQILEERQYLVTALKDIPCVEQVFDSETNYILVR
FTASSAVFKSLWDQGIILRDQNKQPSLSGCLRITVGTRAESQRVLDALKAEKV