Protein Info for EX28DRAFT_0495 in Enterobacter asburiae PDN3

Annotation: capsular exopolysaccharide family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 720 transmembrane" amino acids 32 to 53 (22 residues), see Phobius details amino acids 425 to 448 (24 residues), see Phobius details PF02706: Wzz" amino acids 16 to 107 (92 residues), 75.1 bits, see alignment E=1.4e-24 PF23607: WZC_N" amino acids 111 to 204 (94 residues), 74.1 bits, see alignment E=3.5e-24 PF13807: GNVR" amino acids 367 to 447 (81 residues), 106.9 bits, see alignment E=1.2e-34 TIGR01007: capsular exopolysaccharide family" amino acids 508 to 711 (204 residues), 158.9 bits, see alignment E=6.2e-51 PF01656: CbiA" amino acids 537 to 701 (165 residues), 31.2 bits, see alignment E=5.6e-11 PF13614: AAA_31" amino acids 538 to 650 (113 residues), 47.9 bits, see alignment E=4.7e-16

Best Hits

Swiss-Prot: 87% identical to WZC_ECOLI: Tyrosine-protein kinase wzc (wzc) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 96% identity to enc:ECL_03383)

MetaCyc: 87% identical to protein-tyrosine kinase Wzc (Escherichia coli K-12 substr. MG1655)
Receptor protein-tyrosine kinase. [EC: 2.7.10.1, 2.7.10.2, 2.7.10.3, 2.7.12.1]

Predicted SEED Role

"Tyrosine-protein kinase Wzc (EC 2.7.10.2)" in subsystem Colanic acid biosynthesis (EC 2.7.10.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.10.2

Use Curated BLAST to search for 2.7.10.1 or 2.7.10.2 or 2.7.10.3 or 2.7.12.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (720 amino acids)

>EX28DRAFT_0495 capsular exopolysaccharide family (Enterobacter asburiae PDN3)
MTEKTRPSAAPTSGSDEIDIGRLVGTVVEAKWWVLGITAVFAAAAVVYTLFATPIYSADA
LVQIEQNTGNSLVQDIGSALANKPPASDAEIQLIQSRLVLGKTVHDLGLDISVTKNTFPV
FGAGWDRLMGRNNDTVKVTDFVLPKGAADQTFTLKVLGPKQYQLTSDAGFSARGEVGQML
TKDGVSMMVSAINAQEGGEFTVTKFSTLGMINNLQNNLTVTENGKDTGVLSMTFTGEDKD
QIRDILNSITRNYLEQNVERKSAEAAKSLAFLAKQLPEVRAHLDDAENKLNAYRQDKDSV
DLPLEAKSVLDSMVNIDAQLNELTFKEAEISKLYTKRHPAYRTLLEKRRTLEEEKAKLND
RVTAMPKTQQEIVRLTRDVESGQQVYMQLLNKQQELKITEASTVGDVRIVDPAITQPGVL
KPKKALIILGSIILGLMLSIVGVLLRSLFNRGIESPQVLEESGINVYASIPLSEWQKSRD
SVKTIKGVKRYKQSQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAKNNVLMLTGVSPSIGK
TFVCANLAAVVSQTNKRVLLIDCDMRKGYTHELLGTNNVNGLSEILLGKGEISQSAKPTT
VPKFDLIPRGQVPPNPSELLMSERFTELVEWASKNYDLVLIDTPPILAVTDAAVVGRHAG
TTLMVARYAVNTLKEVETSLSRFEQNGIEVKGVILNSIFRRATGYQDYGYYEYEYKSDSK