Protein Info for EX28DRAFT_0459 in Enterobacter asburiae PDN3

Annotation: Superfamily I DNA and RNA helicases

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 593 PF00580: UvrD-helicase" amino acids 9 to 246 (238 residues), 151.8 bits, see alignment E=4.8e-48 PF13245: AAA_19" amino acids 17 to 246 (230 residues), 69.2 bits, see alignment E=6.3e-23 PF13361: UvrD_C" amino acids 506 to 565 (60 residues), 39.2 bits, see alignment 8.9e-14

Best Hits

KEGG orthology group: None (inferred from 60% identity to aav:Aave_0675)

Predicted SEED Role

"ATP-dependent DNA helicase UvrD/PcrA" in subsystem DNA repair, bacterial UvrD and related helicases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (593 amino acids)

>EX28DRAFT_0459 Superfamily I DNA and RNA helicases (Enterobacter asburiae PDN3)
MFAWDPRDLNPEQAAAVIEPSSIFLIACPGSGKTRTLTYKIAYELSRRTDKRIVVAITYT
HRAADEIQERIEDLGVDTSGLWIGTIHAFCLEWILKPYGIYSPALAQGYRVIDPHDREHL
LERLCAPYKGVTHWDCDYYVTETGYKLGCVDMGKHPIIHKVLKLYFDELAANRQIDFELI
LWYAYSLMRDRSQIAVLLSRVFSHILVDEYQDTKQIQYTIVTSILRAGNGQIKILIVGDP
NQAIYGSLGGYAMPVDEFRTLAGISIKELALSLNYRSSERIISYFSNYSVHATKIKGAGK
HASYPSRVTYNQNVTRSGVHDEIVRLIRMSLTNGHSPENICVLAPQWVLLASTTRKLVAM
LPDQQFDGPGLVPFSNNFDNFWFKLSKILLTDSSPKLLVRRMRWANDVIQDLESFGVDTH
TLTPRILLRESNSLTVNETDGLRYLDQAFNDLLKRLNISQDIHPALLTHREAFFSSSAAR
IERLQKEGATYINQVSFFKKVFRERTGITVSTIHGVKGAEFDVVIAFGLLEGMVPHFNEA
NGSAAASKLLYVLSSRARKNLHLISESGRQRGRYGLYTSTELLAACRFSYDQD