Protein Info for EX28DRAFT_0449 in Enterobacter asburiae PDN3

Annotation: transcriptional regulator, LacI family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 335 PF00356: LacI" amino acids 3 to 48 (46 residues), 53.5 bits, see alignment 2.4e-18 PF00532: Peripla_BP_1" amino acids 63 to 326 (264 residues), 174.5 bits, see alignment E=5.1e-55 PF13377: Peripla_BP_3" amino acids 169 to 330 (162 residues), 74.7 bits, see alignment E=1.4e-24

Best Hits

Swiss-Prot: 57% identical to CSCR_ECOLX: Sucrose operon repressor (cscR) from Escherichia coli

KEGG orthology group: None (inferred from 84% identity to eae:EAE_02230)

Predicted SEED Role

"Sucrose specific transcriptional regulator CscR, LacI family" in subsystem Sucrose utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (335 amino acids)

>EX28DRAFT_0449 transcriptional regulator, LacI family (Enterobacter asburiae PDN3)
MASLKDVAKLANVSLMTVSRALNSPERLKPETLVRVQLAIEQTSYVPDLSAKKIRGAHAS
PKTIGVLALDTVTTPFSVDITLSIEETARMHGWNSFVMNMFTDDNPDAIVDLLLAHRPDG
IIYTTMGLRQVPLPAKLLTLPCVLANCESDGEKVASYIPDDEQGQYTAVRALLAQGYRRP
LCLHLPAGLLATTRRRQGLERACREADLDPHSLAHSYMALGDEHYRDIPSVLLAHMQNGI
PGFDSVICGNDRIAFMVYQTLLAQGLRIPEDVAVIGYDNMVGIGELFLPPLTTVQLPHYE
IGRLSALHIINGEEHQNTTRVESPFLMRDSVVHSS