Protein Info for EX28DRAFT_0088 in Enterobacter asburiae PDN3

Annotation: haloacid dehalogenase superfamily, subfamily IF hydrolase, YfhB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01545: HAD hydrolase, family IF
  • amino acids 3 to 211 (209 residues), 416.9 bits, E=8.4e-130
• PF12710: HAD
  • amino acids 9 to 192 (184 residues), 53.5 bits, E=2.2e-18

Best Hits

Swiss-Prot: 85% identical to PGPC_ECOLI: Phosphatidylglycerophosphatase C (pgpC) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 95% identity to enc:ECL_03897)

MetaCyc: 85% identical to phosphatidylglycerophosphatase C (Escherichia coli K-12 substr. MG1655)
Phosphatidylglycerophosphatase. [EC: 3.1.3.27]

Predicted SEED Role

"Hypothetical protein, similar to phosphoserine phosphatase"

MetaCyc Pathways

• superpathway of phospholipid biosynthesis III (E. coli) (11/12 steps found)
• phosphatidylglycerol biosynthesis I (6/6 steps found)
• phosphatidylglycerol biosynthesis II (6/6 steps found)
• cardiolipin biosynthesis I (3/3 steps found)
• cardiolipin biosynthesis II (3/3 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (10/13 steps found)
• cardiolipin biosynthesis III (2/3 steps found)
• type I lipoteichoic acid biosynthesis (S. aureus) (5/17 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerophospholipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.27

Use Curated BLAST to search for 3.1.3.27

Protein Sequence (211 amino acids)

>EX28DRAFT_0088 haloacid dehalogenase superfamily, subfamily IF hydrolase, YfhB (Enterobacter asburiae PDN3)
MANHGRRVVFFDLDGTLHQQDMFGTFMRYLLRRQPLNALLVLPLLPVIGIALLVKGRAAR
WPMSLLLWGCTFGHSEARLKQLEKDFAHWFRGHVAAFPVVQARLTSYLDANDADIWLITG
SPQTLVEQVYFDTPWLPRVNLIATQISRGYGGWVLTLRCLGHEKVVQLEKRIGTPLRLYS
GYSDSKQDNPLLYFCQHRWRVTPSGELQQLE