Protein Info for EFB2_03660 in Escherichia fergusonii Becca

Annotation: Nuclease SbcCD subunit C

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1047 TIGR00618: exonuclease SbcC" amino acids 1 to 1039 (1039 residues), 1406.2 bits, see alignment E=0 PF13476: AAA_23" amino acids 5 to 206 (202 residues), 100.7 bits, see alignment E=2.6e-32 PF13555: AAA_29" amino acids 26 to 60 (35 residues), 27.2 bits, see alignment (E = 4.1e-10) PF13558: SbcC_Walker_B" amino acids 930 to 1001 (72 residues), 51.5 bits, see alignment 1.4e-17

Best Hits

Swiss-Prot: 97% identical to SBCC_ECOLI: Nuclease SbcCD subunit C (sbcC) from Escherichia coli (strain K12)

KEGG orthology group: K03546, exonuclease SbcC (inferred from 99% identity to ecp:ECP_0456)

MetaCyc: 97% identical to ATP-dependent structure-specific DNA nuclease - SbcC subunit (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Exonuclease SbcC" in subsystem DNA repair, bacterial

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1047 amino acids)

>EFB2_03660 Nuclease SbcCD subunit C (Escherichia fergusonii Becca)
MKILSLRLKNLNSLKGEWKIDFTREPFASNGLFAITGPTGAGKTTLLDAICLALYHETPR
LSNVSQSQNDLMTRDTAECLAEVEFEVKGEAYRAFWSQNRARNQPDGNLQVPRVELARCA
DGKILADKVKDKLELTATLTGLDYGRFTRSMLLSQGQFAAFLNAKPKERAELLEELTGTE
IYGQISAMVFEQHKSARTELEKLQAQASGVALLTPEQVQSLTASLQVLTDEEKQLITAQQ
QEQQSLNWLTRLDELQQEASRRQQALQQALAEEEKAQPQLAALSLAQPARNLRPHWERIA
EHSTALAHTRQQIEEVNTRLQSTMALRASIRHHAAKQSAELQQQQQSLNAWLQEHDRFRQ
WNNELAGWRAQFSQQTSDREHLRQCQQQLTHAEQKLNALAAITLTLTADEVASALAQHAE
QRPLRQRLVALHGQIVPQQKRLAQLQVAIQNVTLEQTQRNAALNEMRHRYKEKTQQLADV
KTICEQETRIKTLEAQRAQLQAGQPCPLCGSTSHPAVEAYQALEPGVNQARLLTLEKEVK
KLGEEVATLRGQLDALTKQLQRDENEAQSLRQDEQALTQQWQAVTASLNITLQPQDDIQP
WLDAQDEHERQLRLLSQRHELQGQIAAHNQQIIQYQQQIEQRQQQLLTALAGYALTLPQE
DEEESWLATRQQEAQSWQHRQNELTALQNRIQQLTPILETLPQSDELPHSEETVVLENWR
QVHEQCLALHSQQQTLQQQDVLAAQSLQKAQAQFDTALQASVFDDQQAFLAALMDEQTLT
QLEQLKQNLENQRRQAQTLVTQTAETLTQHQQHRPGGLSLTVTVEQIQQELAQTHQKLRE
NTTSQGEIRQQLKQDADNRQQQQTLMQQIAQMTQQVEDWGYLNSLIGSKEGDKFRKFAQG
LTLDNLVHLANQQLTRLHGRYLLQRKASEALEVEVVDTWQADAVRDTRTLSGGESFLVSL
ALALALSDLVSHKTRIDSLFLDEGFGTLDSETLDTALDALDALNASGKTIGVISHVEAMK
ERIPVQIKVKKINGLGYSKLESAFAMK