Protein Info for EFB2_03612 in Escherichia fergusonii Becca

Annotation: HTH-type transcriptional regulator SgrR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 566 PF12793: SgrR_N" amino acids 7 to 119 (113 residues), 133.3 bits, see alignment E=4.8e-43 PF00496: SBP_bac_5" amino acids 165 to 303 (139 residues), 61.2 bits, see alignment E=1e-20

Best Hits

Swiss-Prot: 99% identical to YBAE_ECOLI: Uncharacterized protein YbaE (ybaE) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to ecm:EcSMS35_0488)

Predicted SEED Role

"Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1)" in subsystem ABC transporter oligopeptide (TC 3.A.1.5.1) or Sex pheromones in Enterococcus faecalis and other Firmicutes (TC 3.A.1.5.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (566 amino acids)

>EFB2_03612 HTH-type transcriptional regulator SgrR (Escherichia fergusonii Becca)
MRLLNRLNQYQRLWQPSAGKPQTVTVSELAERCFCSERHVRTVLRQAQEAGWLEWQAQSG
RGKRGQLRFLVTPESLRNAMMEQALETGKQQDVLELAQLAPGELRTLLQPFMGGQWQNDT
PTLRIPYYRPLEPLQPGFLPGRAEQHLAGQIFSGLTRFDNNTQRPIGDLAHHWETSTDGL
RWDFYLRSTLHWHNGDAVKASHLHQRLLMLLQLPALDQLFISVKRIEVTHPQCLTFFLHR
PDYWLAHRLASYCSHLAHPQFPLIGTGPFRLTQFTAELVRLESHDYYHLRHPLLKAVEYW
ITPPLFEKDLGTSCRHPVQITIGKPEELQRVSQVSSGISLGFCYLTLRKSPRLSLWQARK
VISIIHQSGLLQTLEVGENLITASHALLPDWTIPQWQVPDEVKLPKTLTLVYHLPIELHT
MAERLQATLAAEGCELTIIFHNAKNWDDTTLLAHADLMMGDRLIGEAPEYTLEQWLRCDP
LWPHVFDAPAYAHLQSTLDAVQVMPDEENRFNALKAVFSQLMADATLTPLFNYHYRISAP
PGVNGVRLTPRGWFEFTEAWLPAPSQ