Protein Info for EFB2_02516 in Escherichia fergusonii Becca

Annotation: putative HTH-type transcriptional regulator YddM

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 75 94 TIGR02607: addiction module antidote protein, HigA family" amino acids 3 to 81 (79 residues), 93.4 bits, see alignment E=2.9e-31 PF01381: HTH_3" amino acids 14 to 65 (52 residues), 36.5 bits, see alignment E=2.1e-13

Best Hits

Swiss-Prot: 100% identical to YDDM_ECOL6: Uncharacterized HTH-type transcriptional regulator YddM (yddM) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: None (inferred from 100% identity to eco:b1477)

Predicted SEED Role

"HigA protein (antitoxin to HigB)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (94 amino acids)

>EFB2_02516 putative HTH-type transcriptional regulator YddM (Escherichia fergusonii Becca)
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVI
GSSPQMWLNLQNAWSLAEAEKTVDVSRLRRLVTQ