Protein Info for EFB2_01913 in Escherichia fergusonii Becca

Annotation: Tyrocidine synthase 3

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2166 transmembrane" amino acids 287 to 304 (18 residues), see Phobius details amino acids 564 to 581 (18 residues), see Phobius details amino acids 1744 to 1757 (14 residues), see Phobius details PF00668: Condensation" amino acids 43 to 477 (435 residues), 291.9 bits, see alignment E=1.6e-90 amino acids 1097 to 1522 (426 residues), 103.9 bits, see alignment E=1.8e-33 PF00501: AMP-binding" amino acids 508 to 844 (337 residues), 248.2 bits, see alignment E=2.5e-77 amino acids 1556 to 1903 (348 residues), 274.2 bits, see alignment E=3.2e-85 TIGR01733: amino acid adenylation domain" amino acids 528 to 918 (391 residues), 363.7 bits, see alignment E=5.9e-113 amino acids 1575 to 1975 (401 residues), 399.3 bits, see alignment E=9e-124 PF13193: AMP-binding_C" amino acids 902 to 976 (75 residues), 30.2 bits, see alignment (E = 1.4e-10) PF00550: PP-binding" amino acids 1007 to 1069 (63 residues), 47.7 bits, see alignment (E = 3.1e-16) amino acids 2067 to 2131 (65 residues), 50.5 bits, see alignment (E = 4e-17)

Best Hits

KEGG orthology group: None (inferred from 100% identity to cko:CKO_00869)

MetaCyc: 100% identical to colibactin non-ribosomal peptide synthetase ClbJ (Escherichia coli IHE3034)
RXN-21149 [EC: 6.2.1.69]; RXN-21148 [EC: 6.2.1.69, 6.2.1.66]; RXN-21119 [EC: 6.2.1.69, 6.2.1.66]; RXN-21120 [EC: 6.2.1.69, 6.2.1.66]

Predicted SEED Role

"iron aquisition yersiniabactin synthesis enzyme (Irp2)"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.66 or 6.2.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (2166 amino acids)

>EFB2_01913 Tyrocidine synthase 3 (Escherichia fergusonii Becca)
MTIHHAALARMLPAEKKEKLLRQLAQSGVSPSRIPIIKADPAQAIPLSFNQERLWFLQKY
DSTATNYNLYVVYRLHGVVDMPMLTEALRHVQARHAILRTRIIVRNDRPCQVIDDASSLV
LDTVTLAAQAPTSALDAVIQQVINTRFDLARGPLWGVTQIIQPDQGCHLVFCAHHIIIDG
ISLRLLFDELQQQYARLHAGNETSLPPPPLQYADYAFWQREWFQDTLLANELAYWRARLQ
DAPLLSTFPSLHPRPAQPSTHGSRFSITLDETLSLALKHVARTQETTPFVLMLTAFQLVL
MRYAQQQRLVIGMPVSGRIRPELQSSIGYYASTAVIYTDFNGVEVGREALQRVKASVKET
QGRQQLPFENLVNMLDLPRSLSHSPLFQILYIYHNHVTPRAFTLAGAYWEQVTYHNQTVK
YDMTVEVFQNDATFDVSFEYDLGLYDADVVKQIAEALRQHCLSLTSSLETPIGAIPLHAP
ETATPRRDPLNATNVPWLGPQDVLRIIEQRCVQHPKQLAIQQHDGTLTYAELWARVQFIA
MRFRAHGIQPGDRIGVLLPRHRDVIATMLATWFVGACYVPFDIHQPAARLQRLMQRARLV
CLVVRQPGEWGEIVQLSLPELMQDMSNAIRYSTPCALLPDMQAYLLFTSGSTGEPKGVCV
VHRGLLNLLLDMQRTFAVGSQDRLLSVTTPTFDISFLEYLLPLISGASLYLTEAERAADS
FRMIPLIADYRPTLMQATPSFWHGLLMAGWRGDPELCVLAGGEALPTKVAEELLRCCGSL
WNLYGPTETTIWSLKSQITQAENITLGAPIANTRIYILDNEGHPVPQGVDGELYIAGDGV
AQGYDGQPELNAQFFLSEPGVPGGRMFRTGDLVRSDAQGQLFFVGRKDSQIKLRGYRIEL
GEIERTLARHPHVDAAVVACIERAPLHKALAAFIITSEPPSLFEQLKNELRQQLPDYMVP
TLWQRVADFPNTDNGKIDRKRLAENFVADSSLVSPQTQALSDTEQMLLALWMRYLPIKNV
DPECDFFRLGGHSLLAVTLVAEINRTFHCALTLKDIFHYSTLRALSARIAQQSITDAAAS
QDDWVIVHDPEHRHQPFPLTDVQRAYWLGRQTGATSIATHIYHEFDVEHFNVTRFTHAVN
ALIARHEMLRARVLPDGTQQILAQVPAYQLEQRDLSALSPNARNDALMAIRDRLSHHVHP
ADRWPLFDFSYSACTAQHGRLHFSLDLLIADALSMRTLQQELMMLYREPHVSLPLLPFSF
RDYVQALLVEQASEAYARDQAYWQRALPQLYGPPTLPVQGDLAQLSAIRFVRRRHRLSAH
NWGVLSALAQRTRITKTALLLTVFSQVLARWSLSPTFTLNLTLFNRPQGYPNAEAVIGDF
TAVSLLNVCYDSQHSYAHNAQRIQVQLWEDLEHRRFSGIRASEALIHSGRFHAPMPVVFT
SMLDIDGETTAQDPRDTTRFTLCPDANITQTPQVWLDHQVIELAGELHFNWDAVEQLFDT
TLLDQMFGAYCHALQALVAMPQSWWGVNSSLALPTVSAPVTQAPAPTALLHHGLLRQAAL
TPQETALISPIRELTYRQLSTAADHVARALLALGVQHGDRVAVVMEKGWQQIAAVHGILR
LGAVYLPVDPVLPPQRRQLLLTVGEVRVQVTQPGLTQLESSLPVLIIDDGMLDTPAAPLP
EVAGDVTDLAYIIFTSGSTGTPKGVMIDHRAAMNTLEDINERFGLNAQDRVFGLSSLSFD
LSVYDAFAPFMVGAALVLPEAGREKDPRHWQTVMAHGHVSVWNAVPALMQMLCEYHSGDR
MSYPTLRLALLSGDWIPLTLPEQMRERLNETMDIISLGGATECAIWSVYYPIGEVESTWT
SIPYGRGLRNQPVYVLNAQLEECPVGVEGEICIGGMGLAQGYLNDAEKTAASFVWREASG
ERIYRTGDRGRYFADGQVAFLGRNDTQVKVNGYRIELGEVKSHLEQLDSVGSAAVVCHQG
QLYAFITAAENLHPDDTDALLARVRAQLAVQLPYYLLPQHFFLLKVLPMTGNGKIDQAAM
VQEVIQRMSQSTSQKSRALAHASPYEQQVAALWCEVLQREQIGLNDNFFEAGGGSIQIVL
LHRRIEEIFKVTVPIAELFRLTTVKRIAGYLQAMQDNARAVNQTQQRDASRSRAQQRLVR
RHQRQR