Protein Info for EFB2_00501 in Escherichia fergusonii Becca

Annotation: Putative general secretion pathway protein B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 139 transmembrane" amino acids 27 to 51 (25 residues), see Phobius details

Best Hits

Swiss-Prot: 97% identical to GSPB_ECOLI: Putative general secretion pathway protein B (gspB) from Escherichia coli (strain K12)

KEGG orthology group: K02451, general secretion pathway protein B (inferred from 97% identity to eco:b3322)

Predicted SEED Role

"PioO protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (139 amino acids)

>EFB2_00501 Putative general secretion pathway protein B (Escherichia fergusonii Becca)
MFEFYIAAREQKETGHPGIFSRQKHSTIIYVICLLLICLWFAGMVLVGGYARQLWALWIV
KAEVTVDAETPAFKQSTQHYFFKKQPLPVVESVEEEDEPGVAVENAPSSSEDEENTVEES
DEKAGLRERVKNALNELER