Protein Info for EFB2_00125 in Escherichia fergusonii Becca

Annotation: Transcriptional regulator ManR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 517 PF08279: HTH_11" amino acids 7 to 63 (57 residues), 33.9 bits, see alignment 6e-12 PF05043: Mga" amino acids 100 to 169 (70 residues), 28.2 bits, see alignment E=5.9e-10 PF00874: PRD" amino acids 209 to 294 (86 residues), 41.2 bits, see alignment E=4.1e-14 amino acids 324 to 413 (90 residues), 61.5 bits, see alignment E=1.9e-20

Best Hits

KEGG orthology group: K02538, activator of the mannose operon, transcriptional antiterminator (inferred from 99% identity to ect:ECIAI39_4185)

Predicted SEED Role

"Transcriptional antiterminator of lichenan operon, BglG family" in subsystem Beta-Glucoside Metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (517 amino acids)

>EFB2_00125 Transcriptional regulator ManR (Escherichia fergusonii Becca)
MQMITSRQNRLLRFLLPRREYTTIVTIAGYLNVSEKTIQRDLRLLEQWLGQWRINVEKRA
GAGVMLSAENIADLLHLDHLLVAECEEIDGVMNNARRVKIASQLLSETPNETSISKLSER
YFISGASIVNDLRVIESWLAPLGLSLIRSPSGTHIEGSEGQVRQAMALLINGIINHNEPQ
GVVYSRLDPGSYKALVHYFGEEEVLFVQSLLLDMENELSWSLGEPYYVNIFTHILIMMYR
NTHGNALSREEDQTRQYDENIFNVASQMIHKIEQRIAHTLPDDEVWFIYQYIISSGVAID
GQKDVSIISHMQASNEARLITWRLITVFSDIVDCDFSEDSALYDGLLVHIKPLINRLNYR
IHIRNPLLEDIKAELADVWRLTQYVVNQVFKTWGENAVSEDEVGYLTVHFQAAMERQIAR
KRVLLVCSTGIGTSHLLKSRILRAFPEWTIVDVISAANLSQVLPDNIELIISTINLPTVT
MPVAYVTAFFNDADIKRVTEMVITEKLHHATSRVVEI