Protein Info for ECD_03828 in Escherichia coli BL21
Annotation: catalase-peroxidase HPI, heme b-containing
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to KATG_ECOLC: Catalase-peroxidase (katG) from Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
KEGG orthology group: K03782, catalase/peroxidase [EC: 1.11.1.6 1.11.1.7] (inferred from 100% identity to ecl:EcolC_4073)MetaCyc: 100% identical to catalase/hydroperoxidase HPI (Escherichia coli K-12 substr. MG1655)
Catalase. [EC: 1.11.1.21, 1.11.1.6]; 1.11.1.21 [EC: 1.11.1.21, 1.11.1.6]
Predicted SEED Role
"Catalase (EC 1.11.1.6) / Peroxidase (EC 1.11.1.7)" in subsystem Oxidative stress or Photorespiration (oxidative C2 cycle) or Auxin degradation (EC 1.11.1.6, EC 1.11.1.7)
MetaCyc Pathways
- reactive oxygen species degradation (4/4 steps found)
- superoxide radicals degradation (2/2 steps found)
- betanidin degradation (1/1 steps found)
- luteolin triglucuronide degradation (3/4 steps found)
- ethanol degradation IV (2/3 steps found)
- baicalein degradation (hydrogen peroxide detoxification) (1/2 steps found)
- methanol oxidation to formaldehyde IV (1/2 steps found)
- xanthommatin biosynthesis (1/4 steps found)
- sesamin biosynthesis (1/8 steps found)
- justicidin B biosynthesis (1/10 steps found)
- matairesinol biosynthesis (1/10 steps found)
KEGG Metabolic Maps
- Biosynthesis of phenylpropanoids
- Methane metabolism
- Phenylalanine metabolism
- Phenylpropanoid biosynthesis
- Tryptophan metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.11.1.6
Use Curated BLAST to search for 1.11.1.21 or 1.11.1.6 or 1.11.1.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (726 amino acids)
>ECD_03828 catalase-peroxidase HPI, heme b-containing (Escherichia coli BL21) MSTSDDIHNTTATGKCPFHQGGHDQSAGAGTTTRDWWPNQLRVDLLNQHSNRSNPLGEDF DYRKEFSKLDYYGLKKDLKALLTESQPWWPADWGSYAGLFIRMAWHGAGTYRSIDGRGGA GRGQQRFAPLNSWPDNVSLDKARRLLWPIKQKYGQKISWADLFILAGNVALENSGFRTFG FGAGREDVWEPDLDVNWGDEKAWLTHRHPEALAKAPLGATEMGLIYVNPEGPDHSGEPLS AAAAIRATFGNMGMNDEETVALIAGGHTLGKTHGAGPTSNVGPDPEAAPIEEQGLGWAST YGSGVGADAITSGLEVVWTQTPTQWSNYFFENLFKYEWVQTRSPAGAIQFEAVDAPEIIP DPFDPSKKRKPTMLVTDLTLRFDPEFEKISRRFLNDPQAFNEAFARAWFKLTHRDMGPKS RYIGPEVPKEDLIWQDPLPQPIYNPTEQDIIDLKFAIADSGLSVSELVSVAWASASTFRG GDKRGGANGARLALMPQRDWDVNAAAVRALPVLEKIQKESGKASLADIIVLAGVVGVEKA ASAAGLSIHVPFAPGRVDARQDQTDIEMFELLEPIADGFRNYRARLDVSTTESLLIDKAQ QLTLTAPEMTALVGGMRVLGANFDGSKNGVFTDRVGVLSNDFFVNLLDMRYEWKATDESK ELFEGRDRETGEVKFTASRVDLVFGSNSVLRAVAEVYASSDAHEKFVKDFVAAWVKVMNL DRFDLL