Protein Info for ECD_03756 in Escherichia coli BL21

Annotation: GTP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 607 PF00009: GTP_EFTU" amino acids 4 to 195 (192 residues), 201.6 bits, see alignment E=2.3e-63 TIGR00231: small GTP-binding protein domain" amino acids 4 to 134 (131 residues), 87.3 bits, see alignment E=9.9e-29 TIGR01394: GTP-binding protein TypA/BipA" amino acids 5 to 599 (595 residues), 973.3 bits, see alignment E=3.9e-297 PF01926: MMR_HSR1" amino acids 8 to 129 (122 residues), 25.6 bits, see alignment E=2.8e-09 PF03144: GTP_EFTU_D2" amino acids 219 to 289 (71 residues), 43.9 bits, see alignment E=6.4e-15 PF00679: EFG_C" amino acids 397 to 477 (81 residues), 80.3 bits, see alignment E=2.2e-26 PF21018: BipA_C" amino acids 485 to 593 (109 residues), 154.8 bits, see alignment E=1.6e-49

Best Hits

Swiss-Prot: 100% identical to TYPA_ECOL6: GTP-binding protein TypA/BipA (typA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K06207, GTP-binding protein (inferred from 100% identity to ecr:ECIAI1_4071)

Predicted SEED Role

"GTP-binding protein TypA/BipA" in subsystem Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (607 amino acids)

>ECD_03756 GTP-binding protein (Escherichia coli BL21)
MIEKLRNIAIIAHVDHGKTTLVDKLLQQSGTFDSRAETQERVMDSNDLEKERGITILAKN
TAIKWNDYRINIVDTPGHADFGGEVERVMSMVDSVLLVVDAFDGPMPQTRFVTKKAFAYG
LKPIVVINKVDRPGARPDWVVDQVFDLFVNLDATDEQLDFPIVYASALNGIAGLDHEDMA
EDMTPLYQAIVDHVPAPDVDLDGPFQMQISQLDYNSYVGVIGIGRIKRGKVKPNQQVTII
DSEGKTRNAKVGKVLGHLGLERIETDLAEAGDIVAITGLGELNISDTVCDTQNVEALPAL
SVDEPTVSMFFCVNTSPFCGKEGKFVTSRQILDRLNKELVHNVALRVEETEDADAFRVSG
RGELHLSVLIENMRREGFELAVSRPKVIFREIDGRKQEPYENVTLDVEEQHQGSVMQALG
ERKGDLKNMNPDGKGRVRLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDDVRPGEV
GQRQNGVLISNGQGKAVAFALFGLQDRGKLFLGHGAEVYEGQIIGIHSRSNDLTVNCLTG
KKLTNMRASGTDEAVVLVPPIRMTLEQALEFIDDDELVEVTPTSIRIRKRHLTENDRRRA
NRAPKDD