Protein Info for ECD_03426 in Escherichia coli BL21

Annotation: transcriptional repressor for the yiaKLMNO-lyxK-sgbHUE operon

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 282 PF09339: HTH_IclR" amino acids 25 to 74 (50 residues), 53.5 bits, see alignment 1.6e-18 PF01614: IclR" amino acids 143 to 268 (126 residues), 150.4 bits, see alignment E=2.5e-48

Best Hits

Swiss-Prot: 100% identical to YIAJ_ECOLI: DNA-binding transcriptional repressor YiaJ (yiaJ) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to eco:b3574)

Predicted SEED Role

"Transcriptional regulator, IclR family" in subsystem Homogentisate pathway of aromatic compound degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (282 amino acids)

>ECD_03426 transcriptional repressor for the yiaKLMNO-lyxK-sgbHUE operon (Escherichia coli BL21)
MGKEVMGKKENEMAQEKERPAGSQSLFRGLMLIEILSNYPNGCPLAHLSELAGLNKSTVH
RLLQGLQSCGYVTTAPAAGSYRLTTKFIAVGQKALSSLNIIHIAAPHLEALNIATGETIN
FSSREDDHAILIYKLEPTTGMLRTRAYIGQHMPLYCSAMGKIYMAFGHPDYVKSYWESHQ
HEIQPLTRNTITELPAMFDELAHIRESGAAMDREENELGVSCIAVPVFDIYGRVPYAVSI
SLSTSRLKQVGEKNLLKPLRETAQAISNELGFTVRDDLGAIT