Protein Info for ECD_03086 in Escherichia coli BL21

Annotation: sialic acid-inducible nan operon repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 263 PF00392: GntR" amino acids 32 to 95 (64 residues), 73.1 bits, see alignment E=1.2e-24 PF07729: FCD" amino acids 126 to 246 (121 residues), 74 bits, see alignment E=1.5e-24

Best Hits

Swiss-Prot: 100% identical to NANR_ECO55: HTH-type transcriptional repressor NanR (nanR) from Escherichia coli (strain 55989 / EAEC)

KEGG orthology group: None (inferred from 100% identity to eco:b3226)

Predicted SEED Role

"Transcriptional regulator NanR" in subsystem Sialic Acid Metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (263 amino acids)

>ECD_03086 sialic acid-inducible nan operon repressor (Escherichia coli BL21)
MGLMNAFDSQTEDSSPAIGRNLRSRPLARKKLSEMVEEELEQMIRRREFGEGEQLPSERE
LMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTIIGELSGMAKDFLSHPGG
IAHFEQLRLFFESSLVRYAAEHATDEQIDLLAKALEINSQSLDNNAAFIRSDVDFHRVLA
EIPGNPIFMAIHVALLDWLIAARPTVADQALHEHNNVSYQQHIAIVDAIRRHDPDEADRA
LQSHLNSVSATWHAFGQTTNKKK