Protein Info for ECD_03002 in Escherichia coli BL21

Annotation: N-acetylgalactosamine-6-phosphate deacetylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00221: N-acetylglucosamine-6-phosphate deacetylase
  • amino acids 3 to 372 (370 residues), 288.4 bits, E=4.1e-90
• PF01979: Amidohydro_1
  • amino acids 47 to 364 (318 residues), 64 bits, E=7.5e-22

Best Hits

Swiss-Prot: 98% identical to AGAA_ECO57: N-acetylgalactosamine-6-phosphate deacetylase (agaA) from Escherichia coli O157:H7

KEGG orthology group: K02079, N-acetylgalactosamine-6-phosphate deacetylase [EC: 3.5.1.25] (inferred from 97% identity to efe:EFER_4356)

MetaCyc: 98% identical to N-acetylglucosamine-6-phosphate deacetylase (Escherichia coli O157:H7)
N-acetylglucosamine-6-phosphate deacetylase. [EC: 3.5.1.25]

Predicted SEED Role

"N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)" in subsystem Chitin and N-acetylglucosamine utilization or Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 3.5.1.25)

MetaCyc Pathways

• superpathway of N-acetylneuraminate degradation (22/22 steps found)
• peptidoglycan recycling I (14/14 steps found)
• superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation (6/6 steps found)
• D-galactosamine and N-acetyl-D-galactosamine degradation (4/4 steps found)
• N-acetylglucosamine degradation I (2/2 steps found)
• N-acetyl-D-galactosamine degradation (4/5 steps found)
• N-acetylglucosamine degradation II (2/3 steps found)
• chitin derivatives degradation (3/8 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Galactose metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.25

Use Curated BLAST to search for 3.5.1.25

Protein Sequence (377 amino acids)

>ECD_03002 N-acetylgalactosamine-6-phosphate deacetylase (Escherichia coli BL21)
MTHVLRARRLLTEEGWLDDHQLRIADGVIAAIEPIPAGVTERDAELLCPAYIDTHVHGGA
GVDVMDDAPDVLDKLAMHKAREGVGSWLPTTVTAPLNTIHAALKRIAQRCQRGGPGAQVL
GSYLEGPYFTPQNKGAHPPELFRELEIAELDQLIAVSQHTLRVVALAPEKEGALQAIRHL
KQQNVRVMLGHSAATWQQTRAAFDAGADGLVHCYNGMTGLHHREPGMVGAGLTDKRAWLE
LIADGHHVHPAAMSLCCCCAKERIVMITDAMQAAGMPDGRYTLCGEEVQMHGGVVRTASG
GLAGSTLSVDAAVRNMVELTGVTPAEAIHMASLHPARMLGVDGVLGSLKPGKRASIVALD
SGLHVQQIWIQSQLASF