Protein Info for ECD_02717 in Escherichia coli BL21

Annotation: guanine/hypoxanthine permease, high affinity; guanine/hypoxanthine:H+ symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 455 transmembrane" amino acids 35 to 56 (22 residues), see Phobius details amino acids 62 to 83 (22 residues), see Phobius details amino acids 89 to 108 (20 residues), see Phobius details amino acids 114 to 138 (25 residues), see Phobius details amino acids 147 to 171 (25 residues), see Phobius details amino acids 178 to 203 (26 residues), see Phobius details amino acids 210 to 230 (21 residues), see Phobius details amino acids 255 to 278 (24 residues), see Phobius details amino acids 310 to 327 (18 residues), see Phobius details amino acids 339 to 383 (45 residues), see Phobius details amino acids 395 to 423 (29 residues), see Phobius details amino acids 434 to 454 (21 residues), see Phobius details PF00860: Xan_ur_permease" amino acids 32 to 415 (384 residues), 271 bits, see alignment E=7.1e-85

Best Hits

Swiss-Prot: 100% identical to GHXQ_ECOLI: Guanine/hypoxanthine permease GhxQ (ghxQ) from Escherichia coli (strain K12)

KEGG orthology group: K06901, putative MFS transporter, AGZA family, xanthine/uracil permease (inferred from 100% identity to eco:b4464)

MetaCyc: 100% identical to guanine/hypoxanthine transporter GhxQ (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-562; TRANS-RXN0-578

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (455 amino acids)

>ECD_02717 guanine/hypoxanthine permease, high affinity; guanine/hypoxanthine:H+ symporter (Escherichia coli BL21)
MSGDILQTPDAPKPQGALDNYFKITARGSTVRQEVLAGLTTFLAMVYSVIVVPGMLGKAG
FPPAAVFVATCLVAGFGSLLMGLWANLPMAIGCAISLTAFTAFSLVLGQQISVPVALGAV
FLMGVIFTAISVTGVRTWILRNLPMGIAHGTGIGIGLFLLLIAANGVGMVIKNPIEGLPV
ALGAFTSFPVMMSLLGLAVIFGLEKCRVPGGILLVIIAISIIGLIFDPAVKYHGLVAMPS
LTGEDGKSLIFSLDIMGALQPTVLPSVLALVMTAVFDATGTIRAVAGQANLLDKDNQIIN
GGKALTSDSVSSIFSGLVGAAPAAVYIESAAGTAAGGKTGLTATVVGALFLLILFLSPLS
FLIPGYATAPALMYVGLLMLSNVSKLDFNDFIDAMAGLVCAVFIVLTCNIVTGIMLGFVT
LVVGRVFAREWQKLNIGTVIITAALVAFYAGGWAI