Protein Info for ECD_02644 in Escherichia coli BL21

Annotation: L-1,2-propanediol oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02638: lactaldehyde reductase
  • amino acids 3 to 379 (377 residues), 661.8 bits, E=1.3e-203
• PF00465: Fe-ADH
  • amino acids 12 to 178 (167 residues), 161.4 bits, E=2.3e-51
• PF13685: Fe-ADH_2
  • amino acids 14 to 112 (99 residues), 42.6 bits, E=9.9e-15
• PF25137: ADH_Fe_C
  • amino acids 191 to 383 (193 residues), 243.4 bits, E=2.5e-76

Best Hits

Swiss-Prot: 100% identical to FUCO_ECOLI: Lactaldehyde reductase (fucO) from Escherichia coli (strain K12)

KEGG orthology group: K00048, lactaldehyde reductase [EC: 1.1.1.77] (inferred from 100% identity to eco:b2799)

MetaCyc: 100% identical to L-1,2-propanediol oxidoreductase (Escherichia coli K-12 substr. MG1655)
Lactaldehyde reductase. [EC: 1.1.1.77]; 1.1.1.77 [EC: 1.1.1.77]

Predicted SEED Role

"Lactaldehyde reductase (EC 1.1.1.77)" in subsystem L-fucose utilization or L-rhamnose utilization (EC 1.1.1.77)

MetaCyc Pathways

• superpathway of fucose and rhamnose degradation (11/12 steps found)
• superpathway of glycol metabolism and degradation (7/7 steps found)
• ethylene glycol degradation (2/2 steps found)
• L-lactaldehyde degradation (anaerobic) (1/1 steps found)
• methylglyoxal degradation VI (1/4 steps found)
• nucleoside and nucleotide degradation (halobacteria) (2/6 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.77

Protein Sequence (383 amino acids)

>ECD_02644 L-1,2-propanediol oxidoreductase (Escherichia coli BL21)
MMANRMILNETAWFGRGAVGALTDEVKRRGYQKALIVTDKTLVQCGVVAKVTDKMDAAGL
AWAIYDGVVPNPTITVVKEGLGVFQNSGADYLIAIGGGSPQDTCKAIGIISNNPEFADVR
SLEGLSPTNKPSVPILAIPTTAGTAAEVTINYVITDEEKRRKFVCVDPHDIPQVAFIDAD
MMDGMPPALKAATGVDALTHAIEGYITRGAWALTDALHIKAIEIIAGALRGSVAGDKDAG
EEIALGQYVAGMGFSNVGLGLVHGMAHPLGAFYNTPHGVANAILLPHVMRYNADFTGEKY
RDIARVMGVKVEGMSLEEARNAAVEAVFALNRDVGIPPHLRDVGVRKEDIPALAQAALND
VCTGGNPREATLEDIVELYHTAW