Protein Info for ECD_02283 in Escherichia coli BL21

Annotation: oxalyl CoA decarboxylase, ThDP-dependent

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 564 TIGR03254: oxalyl-CoA decarboxylase" amino acids 6 to 559 (554 residues), 1045.6 bits, see alignment E=0 PF02776: TPP_enzyme_N" amino acids 9 to 125 (117 residues), 113.4 bits, see alignment E=8.2e-37 PF00205: TPP_enzyme_M" amino acids 202 to 327 (126 residues), 117.9 bits, see alignment E=4.3e-38 PF02775: TPP_enzyme_C" amino acids 403 to 540 (138 residues), 90 bits, see alignment E=2.2e-29

Best Hits

Swiss-Prot: 100% identical to OXC_ECO57: Oxalyl-CoA decarboxylase (oxc) from Escherichia coli O157:H7

KEGG orthology group: K01577, oxalyl-CoA decarboxylase [EC: 4.1.1.8] (inferred from 100% identity to eco:b2373)

MetaCyc: 100% identical to oxalyl-CoA decarboxylase (Escherichia coli K-12 substr. MG1655)
Oxalyl-CoA decarboxylase. [EC: 4.1.1.8]

Predicted SEED Role

"Oxalyl-CoA decarboxylase (EC 4.1.1.8)" in subsystem Alkaloid biosynthesis from L-lysine (EC 4.1.1.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (564 amino acids)

>ECD_02283 oxalyl CoA decarboxylase, ThDP-dependent (Escherichia coli BL21)
MSDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYA
AAASGFLTQKPGICLTVSAPGFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEE
LDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPGGVYLDLPANVLAATMEKDEA
LTTIVKVENPSPALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQADEQLREFIESAQI
PFLPMSMAKGILEDTHPLSAAAARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQ
LDIEPQEIDSNRPIAVPVVGDIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMH
EKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLDNARNIIDMYKPRRRLDCGTW
GVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRG
DGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINV
VIDPAAGTESGHITKLNPKQVAGN