Protein Info for ECD_01981 in Escherichia coli BL21

Annotation: multidrug efflux system, subunit C

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1025 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 336 to 353 (18 residues), see Phobius details amino acids 360 to 384 (25 residues), see Phobius details amino acids 390 to 411 (22 residues), see Phobius details amino acids 431 to 451 (21 residues), see Phobius details amino acids 463 to 490 (28 residues), see Phobius details amino acids 527 to 545 (19 residues), see Phobius details amino acids 852 to 871 (20 residues), see Phobius details amino acids 878 to 895 (18 residues), see Phobius details amino acids 900 to 917 (18 residues), see Phobius details amino acids 953 to 970 (18 residues), see Phobius details amino acids 982 to 1008 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1008 (1005 residues), 1249.7 bits, see alignment E=0 PF03176: MMPL" amino acids 329 to 498 (170 residues), 25.9 bits, see alignment E=7.2e-10 amino acids 788 to 1013 (226 residues), 21 bits, see alignment E=2.2e-08 PF02355: SecD_SecF" amino acids 339 to 485 (147 residues), 23.6 bits, see alignment E=4.7e-09

Best Hits

Swiss-Prot: 100% identical to MDTC_ECOLC: Multidrug resistance protein MdtC (mdtC) from Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

KEGG orthology group: K07789, RND superfamily, multidrug transport protein MdtC (inferred from 61% identity to axy:AXYL_00556)

MetaCyc: 100% identical to multidrug efflux pump RND permease subunit MdtC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-353; TRANS-RXN-92

Predicted SEED Role

"Multidrug transporter MdtC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1025 amino acids)

>ECD_01981 multidrug efflux system, subunit C (Escherichia coli BL21)
MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMA
SSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLP
SGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGS
SLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAE
YQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSI
RAKLPELQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATI
IPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKP
LQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLT
LTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALN
IWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTG
GSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNAS
YQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDV
QAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSY
FAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAG
TAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNA
PFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLA
ALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPK
QTVTE