Protein Info for ECD_01930 in Escherichia coli BL21
Annotation: UDP-glucose 6-dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to UDG_ECOL6: UDP-glucose 6-dehydrogenase (ugd) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
KEGG orthology group: K00012, UDPglucose 6-dehydrogenase [EC: 1.1.1.22] (inferred from 100% identity to eco:b2028)MetaCyc: 100% identical to UDP-glucose 6-dehydrogenase (Escherichia coli K-12 substr. MG1655)
UDP-glucose 6-dehydrogenase. [EC: 1.1.1.22]
Predicted SEED Role
No annotation
MetaCyc Pathways
- colanic acid building blocks biosynthesis (10/11 steps found)
- UDP-α-D-glucuronate biosynthesis (from UDP-glucose) (1/1 steps found)
- UDP-α-D-xylose biosynthesis (1/2 steps found)
- superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (3/6 steps found)
- UDP-sugars interconversion (1/9 steps found)
- teichuronic acid biosynthesis (B. subtilis 168) (1/9 steps found)
KEGG Metabolic Maps
- Ascorbate and aldarate metabolism
- Nucleotide sugars metabolism
- Pentose and glucuronate interconversions
- Starch and sucrose metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.22
Use Curated BLAST to search for 1.1.1.22
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (388 amino acids)
>ECD_01930 UDP-glucose 6-dehydrogenase (Escherichia coli BL21) MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIH FNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVP VGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGERSERAERFAALLQEGAIK QNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNSRQIIEGVCLDPRIGN HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVG IYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQA DVIISNRMAEELKDVADKVYTRDLFGSD