Protein Info for ECD_01401 in Escherichia coli BL21

Annotation: gamma-aminobutyraldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03374: 1-pyrroline dehydrogenase
  • amino acids 2 to 473 (472 residues), 1034.5 bits, E=0
• PF00171: Aldedh
  • amino acids 13 to 470 (458 residues), 561.2 bits, E=8e-173

Best Hits

Swiss-Prot: 100% identical to ABDH_ECO8A: Gamma-aminobutyraldehyde dehydrogenase (prr) from Escherichia coli O8 (strain IAI1)

KEGG orthology group: K00137, aminobutyraldehyde dehydrogenase [EC: 1.2.1.19] (inferred from 100% identity to eco:b1444)

MetaCyc: 100% identical to gamma-aminobutyraldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Aminobutyraldehyde dehydrogenase. [EC: 1.2.1.19]; 1.2.1.19 [EC: 1.2.1.19]

Predicted SEED Role

"4-aminobutyraldehyde dehydrogenase (EC 1.2.1.19)" in subsystem Polyamine Metabolism (EC 1.2.1.19)

MetaCyc Pathways

• superpathway of L-arginine and L-ornithine degradation (13/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (11/11 steps found)
• superpathway of ornithine degradation (8/8 steps found)
• L-lysine degradation I (7/7 steps found)
• L-lysine degradation X (5/6 steps found)
• putrescine degradation I (2/2 steps found)
• putrescine degradation IV (2/3 steps found)
• putrescine degradation V (1/2 steps found)
• superpathway of L-lysine degradation (15/43 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.19

Protein Sequence (474 amino acids)

>ECD_01401 gamma-aminobutyraldehyde dehydrogenase (Escherichia coli BL21)
MQHKLLINGELVSGEGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAADAAFAEWGQTTP
KVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNG
LAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLT
ALKLAELAKDIFPAGVINILFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSI
KRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKL
GAAVATLKSGAPDDESTELGPLSSLAHLERVSKAVEEAKATGHIKVITGGEKRKGNGYYY
APTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHR
VSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVKH