Protein Info for ECD_00920 in Escherichia coli BL21

Annotation: DUF1006 family protein with C-terminal wHTH domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 410 PF06224: AlkZ-like" amino acids 38 to 381 (344 residues), 274.9 bits, see alignment E=6.4e-86

Best Hits

Swiss-Prot: 100% identical to YCAQ_ECOLI: Uncharacterized protein YcaQ (ycaQ) from Escherichia coli (strain K12)

KEGG orthology group: K09927, hypothetical protein (inferred from 100% identity to eco:b0916)

MetaCyc: 100% identical to interstrand DNA crosslink repair glycosylase (Escherichia coli K-12 substr. MG1655)
3.2.2.-; 3.2.2.-

Predicted SEED Role

"FIG004798: Putative cytoplasmic protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (410 amino acids)

>ECD_00920 DUF1006 family protein with C-terminal wHTH domain (Escherichia coli BL21)
MSLPHLSLADARNLHLAAQGLLNKPRRRASLEDIPATISRMSLLQIDTINIVARSPYLVL
FSRLGNYPAQWLDESLARGELMEYWAHEACFMPRSDFRLIRHRMLAPEKMGWKYKDAWMQ
EHEAEIAQLIQHIHDKGPVRSADFEHPRKGASGWWEWKPHKRHLEGLFTAGKVMVIERRN
FQRVYDLTHRVMPDWDDERDLVSQTEAEIIMLDNSARSLGIFREQWLADYYRLKRPALAA
WREARAEQQQIIAVHVEKLGNLWLHDDLLPLLERALAGKLTATHSAVLSPFDPVVWDRKR
AEQLFDFSYRLECYTPAPKRQYGYFVLPLLHRGQLVGRMDAKMHRQTGILEVISLWLQEG
IKPTTTLQKGLRQAITDFANWQQATRVTLGCCPQGLFTDCRTGWEIDPVA