Protein Info for DZA65_RS22510 in Dickeya dianthicola ME23

Annotation: 3-oxoacyl-ACP reductase FabG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00106: adh_short
  • amino acids 4 to 192 (189 residues), 171.9 bits, E=1.8e-54
• PF08659: KR
  • amino acids 5 to 158 (154 residues), 65.2 bits, E=1.1e-21
• TIGR01831: putative 3-oxoacyl-(acyl-carrier-protein) reductase
  • amino acids 5 to 243 (239 residues), 424.1 bits, E=6.7e-132
• PF13561: adh_short_C2
  • amino acids 9 to 242 (234 residues), 177.2 bits, E=6.5e-56

Best Hits

Swiss-Prot: 57% identical to FABG_AGGAC: 3-oxoacyl-[acyl-carrier-protein] reductase FabG (fabG) from Aggregatibacter actinomycetemcomitans

KEGG orthology group: K00059, 3-oxoacyl-[acyl-carrier protein] reductase [EC: 1.1.1.100] (inferred from 92% identity to ddc:Dd586_4180)

MetaCyc: 42% identical to 3-oxoacyl-[acyl-carrier-protein] reductase (Bacillus subtilis subtilis 168)
3-oxoacyl-[acyl-carrier-protein] reductase. [EC: 1.1.1.100]

Predicted SEED Role

"3-oxoacyl-[ACP] reductase (EC 1.1.1.100)" (EC 1.1.1.100)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (51/53 steps found)
• palmitate biosynthesis III (28/29 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
• superpathway of unsaturated fatty acids biosynthesis (E. coli) (20/20 steps found)
• anteiso-branched-chain fatty acid biosynthesis (30/34 steps found)
• even iso-branched-chain fatty acid biosynthesis (30/34 steps found)
• odd iso-branched-chain fatty acid biosynthesis (30/34 steps found)
• tetradecanoate biosynthesis (mitochondria) (23/25 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (16/16 steps found)
• biotin biosynthesis I (15/15 steps found)
• octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) (12/12 steps found)
• 8-amino-7-oxononanoate biosynthesis I (11/11 steps found)
• oleate biosynthesis IV (anaerobic) (13/14 steps found)
• palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) (9/9 steps found)
• (5Z)-dodecenoate biosynthesis I (6/6 steps found)
• cis-vaccenate biosynthesis (5/5 steps found)
• fatty acid elongation -- saturated (5/5 steps found)
• gondoate biosynthesis (anaerobic) (4/4 steps found)
• (5Z)-dodecenoate biosynthesis II (5/6 steps found)
• stearate biosynthesis II (bacteria and plants) (5/6 steps found)
• 8-amino-7-oxononanoate biosynthesis IV (4/5 steps found)
• stearate biosynthesis IV (4/6 steps found)
• petroselinate biosynthesis (2/6 steps found)
• 2-allylmalonyl-CoA biosynthesis (2/8 steps found)
• streptorubin B biosynthesis (20/34 steps found)
• mycolate biosynthesis (20/205 steps found)
• superpathway of mycolate biosynthesis (21/239 steps found)

KEGG Metabolic Maps

• Biosynthesis of unsaturated fatty acids
• Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.100

Use Curated BLAST to search for 1.1.1.100

Sequence Analysis Tools

See A0A3A4CT67 at UniProt or InterPro

Protein Sequence (243 amino acids)

>DZA65_RS22510 3-oxoacyl-ACP reductase FabG (Dickeya dianthicola ME23)
MTRSVLVTGASKGIGRAIALRLAQDGFLVVVHYHRDRNGADETLEQITRLSGQGRCIQFD
IADREPCRTAIESDIEVHGAYYGVVSNAGITCDGAFPALDEQAWDSVIHTNLDSFYNVIH
PCVMPMIGLRQGGRIITLSSVSGIMGNRGQVNYSAAKAGIIGATKALAIELAKRKITVNC
IAPGLIETGMTQLEPVVTDEAMKLIPMKRMGQADEVAGLAGYLMSDIAGYVTRQVISING
GML