Protein Info for DZA65_RS22425 in Dickeya dianthicola ME23

Annotation: glutamine--fructose-6-phosphate transaminase (isomerizing)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 611 (610 residues), 863.4 bits, E=4.4e-264
• PF13522: GATase_6
  • amino acids 67 to 184 (118 residues), 63 bits, E=5.9e-21
• PF13537: GATase_7
  • amino acids 81 to 197 (117 residues), 50.3 bits, E=4.4e-17
• PF01380: SIS
  • amino acids 291 to 419 (129 residues), 116.8 bits, E=1.2e-37
  • amino acids 463 to 593 (131 residues), 90.9 bits, E=1.2e-29

Best Hits

Swiss-Prot: 90% identical to GLMS_PECAS: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 98% identity to ddd:Dda3937_00141)

MetaCyc: 84% identical to L-glutamine--D-fructose-6-phosphate aminotransferase (Escherichia coli K-12 substr. MG1655)
Glutamine--fructose-6-phosphate transaminase (isomerizing). [EC: 2.6.1.16]

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (5/9 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (8/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.16

Sequence Analysis Tools

See A0A3A4DDG5 at UniProt or InterPro

Protein Sequence (611 amino acids)

>DZA65_RS22425 glutamine--fructose-6-phosphate transaminase (isomerizing) (Dickeya dianthicola ME23)
MCGIVGAVAQRDIAEILLEGLRRLEYRGYDSAGLAVLNGEGQVSRLRRLGKVQVLAQAAE
EQPLVGGTGIAHTRWATHGEPSEQNAHPHVSEHIIVVHNGIIENHEPLRELMVSRGYRFV
SETDTEVVAHLVHWEQQQSGGSLLDIVQRVIPQLRGAYGMVLLDSRDPSVLVAARSGSPL
VIGRGVGENFIASDQLALLPVTRRFIFLEEGDIAEVTRRTVRIVNRQGQDVNRDEIESKV
QYDAGDKGVYRHYMQKEIYEQPMAIKNTLEGRFSHGEINLSELGPQADALLAQVQHIQII
ACGTSYNSGMVSRYWFESLAGIPCDVEIASEFRYRKPALRANSLMITLSQSGETADTLAA
LRLSKELGYLGSLAICNVAGSSLVRESDLALMTRAGTEIGVASTKAFTTQLTVLLMLVAR
IGRLRGMDARIEHDIVHALQALPARIEQMLSQDKLIESLAEGFSDKHHALFLGRGDQYPI
AMEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVVAPNNDLLEKLKSNIEEVRA
RGGELYVFADEQAGFTSDSDMMKIIQLPHVEEVIAPIFYTVPLQLLSYHVALIKGTDVDQ
PRNLAKSVTVE