Protein Info for DZA65_RS22255 in Dickeya dianthicola ME23

Annotation: molybdenum cofactor guanylyltransferase MobA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 191 TIGR02665: molybdenum cofactor guanylyltransferase" amino acids 2 to 183 (182 residues), 236.1 bits, see alignment E=1.5e-74 PF12804: NTP_transf_3" amino acids 4 to 158 (155 residues), 139.2 bits, see alignment E=7.1e-45

Best Hits

Swiss-Prot: 61% identical to MOBA_YERPY: Molybdenum cofactor guanylyltransferase (mobA) from Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

KEGG orthology group: K03752, molybdopterin-guanine dinucleotide biosynthesis protein A (inferred from 91% identity to ddd:Dda3937_01108)

MetaCyc: 46% identical to molybdenum cofactor guanylyltransferase (Escherichia coli K-12 substr. MG1655)
RXN-21601 [EC: 2.7.7.77]; 2.7.7.77 [EC: 2.7.7.77]

Predicted SEED Role

"Molybdopterin-guanine dinucleotide biosynthesis protein MobA" in subsystem Molybdenum cofactor biosynthesis

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.77

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385Y6W1 at UniProt or InterPro

Protein Sequence (191 amino acids)

>DZA65_RS22255 molybdenum cofactor guanylyltransferase MobA (Dickeya dianthicola ME23)
MITGVILAGGQSSRMGGNDKGLIELEGRPLYQHVLDRLNPQVETLLINANRHRERYQQSG
YPVIGDINRNFSGPLAGIFTGLSTAKTDWVVFVPCDVPALPLDLVSRLLQFNDNHLAAYA
TDGSREHPTLLAIHTSLVDKLKAYLINGDRKLMLFLEQIEAKAVSFADQPLAFRNLNTPE
DLARWRESHHD