Protein Info for DZA65_RS22235 in Dickeya dianthicola ME23

Annotation: DNA polymerase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 944 TIGR00593: DNA polymerase I" amino acids 9 to 944 (936 residues), 949.7 bits, see alignment E=1e-289 PF02739: 5_3_exonuc_N" amino acids 9 to 170 (162 residues), 201.4 bits, see alignment E=1.6e-63 PF01367: 5_3_exonuc" amino acids 171 to 271 (101 residues), 107.3 bits, see alignment E=9.9e-35 PF01612: DNA_pol_A_exo1" amino acids 330 to 533 (204 residues), 119.7 bits, see alignment E=2.5e-38 PF00476: DNA_pol_A" amino acids 567 to 941 (375 residues), 553.9 bits, see alignment E=3.8e-170

Best Hits

Predicted SEED Role

"DNA polymerase I (EC 2.7.7.7)" in subsystem DNA-replication or DNA Repair Base Excision (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CWI2 at UniProt or InterPro

Protein Sequence (944 amino acids)

>DZA65_RS22235 DNA polymerase I (Dickeya dianthicola ME23)
MVQIADNPLILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLLQQYHPSHVAV
VFDAKGKTFRDDLFEHYKSHRPPMPDDLRAQIEPLHRMVKAMGLPLLSVSGVEADDVIGT
LAQQAERAGKPVLISTGDKDMAQLVTPNITLINTMNNTILGPDEVCAKYGIPPSLIIDFL
ALMGDSSDNIPGVPGVGEKTAQALLAGLGGLDALYADLDKIAGLTFRGAKTMAAKLEQNK
EVAYLSYQLATIKTDVELELGCEQLTVNEPDAVELRELFTRYEFKRWLADVEAGQWLQGG
KKNPPATPFVKATAGGEPKEAASVLSQDGYVTILDEKVLLDWLERIKTAALFSFDTETDG
LDTLTANLVGVSLAIKPGEAAYLPLGHITSRVYSSNIYSSTVSPATRMSTQLGSDRVLAL
LKPLLEDEGIRKIGQNLKFDKGVMARCGIDLRGIAFDTMLESYVLDSVAGRHDMDSLSER
YLQHKTITFEEIAGKGKKQLTFDRIPLAQASVYAAEDADVTLRLHETLWAKLEPQQELRK
VFQNIDMPLVPVLSRIERTGVLINTAILAEHSRELTQRLAELEVQAHELAGEAFNLSSPK
QLGAILYEKLQLPVIKKTPKGAPSTNEEVLVELALDYPLPKLILEHRGLAKLKSTYTDKL
PQMINPLTKRVHTSYHQAVTATGRLSSSDPNLQNIPVRNEEGRRIRQAFIAPEGYRILAA
DYSQIELRIMAHLSRDAGLLRAFSHGLDIHRATAAEVFGLPLDRVTTEQRRSAKAINFGL
IYGMSAFGLSRQLAIPRNEAQKYMNLYFERYPGVQEYMERTRQQAAAQGYVSTLDGRRLY
LPDIHSRNANSRKAAERAAINAPMQGTAADIIKKAMIAIDAWLQQEKPLVTMLMQVHDEL
VFEVHHSVLDETSEKIRNLMEGCMQLDVPLQVDIGTGSNWDQAH