Protein Info for DZA65_RS20325 in Dickeya dianthicola ME23

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 185 PF01396: zf-C4_Topoisom" amino acids 12 to 48 (37 residues), 55 bits, see alignment 2.7e-19 amino acids 61 to 97 (37 residues), 56.8 bits, see alignment 7.7e-20 amino acids 104 to 141 (38 residues), 48.2 bits, see alignment 3.7e-17

Best Hits

Swiss-Prot: 73% identical to YRDD_ECOLI: Uncharacterized protein YrdD (yrdD) from Escherichia coli (strain K12)

KEGG orthology group: K07479, putative DNA topoisomerase (inferred from 95% identity to ddd:Dda3937_01526)

Predicted SEED Role

"Similar to C-terminal Zn-finger domain of DNA topoisomerase I" in subsystem Conserved gene cluster associated with Met-tRNA formyltransferase or DNA topoisomerases, Type I, ATP-independent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385Y2C1 at UniProt or InterPro

Protein Sequence (185 amino acids)

>DZA65_RS20325 hypothetical protein (Dickeya dianthicola ME23)
MTKTILIAEKQQVCPECGAVLVIRSGQHGPFLGCSRYPECHYIRPLKAYADGHVVKVLDG
QHCPRCQSALVLRQGRYGMFICCSNYPECEHTEAIDRPDETTLTCPQCHEGRLLQRKSRY
GKTFHSCERYPACQFTLNHKPIAGECEYCHYPLLIEKKTAQGVRRFCASKLCGKPVSAEE
SHCDE