Protein Info for DZA65_RS20230 in Dickeya dianthicola ME23

Annotation: Na/Pi cotransporter family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 548 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details transmembrane" amino acids 47 to 69 (23 residues), see Phobius details amino acids 76 to 98 (23 residues), see Phobius details amino acids 104 to 122 (19 residues), see Phobius details amino acids 133 to 154 (22 residues), see Phobius details amino acids 175 to 196 (22 residues), see Phobius details amino acids 206 to 226 (21 residues), see Phobius details amino acids 238 to 261 (24 residues), see Phobius details amino acids 275 to 295 (21 residues), see Phobius details TIGR00704: Na/Pi-cotransporter II-related protein" amino acids 1 to 306 (306 residues), 354.1 bits, see alignment E=8.8e-110 PF02690: Na_Pi_cotrans" amino acids 13 to 147 (135 residues), 125.4 bits, see alignment E=1.7e-40 TIGR01013: sodium-dependent inorganic phosphate (Pi) transporter" amino acids 67 to 520 (454 residues), 408.8 bits, see alignment E=3.1e-126 PF01895: PhoU" amino acids 340 to 422 (83 residues), 38.6 bits, see alignment E=1.2e-13

Best Hits

Swiss-Prot: 71% identical to YJBB_ECO57: Uncharacterized protein YjbB (yjbB) from Escherichia coli O157:H7

KEGG orthology group: K03324, phosphate:Na+ symporter (inferred from 97% identity to ddd:Dda3937_02133)

Predicted SEED Role

"Sodium-dependent phosphate transporter" in subsystem Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CEH5 at UniProt or InterPro

Protein Sequence (548 amino acids)

>DZA65_RS20230 Na/Pi cotransporter family protein (Dickeya dianthicola ME23)
MLTLLHLLSAIALLVWGTHIVRTGIMRVYGARLRRTISDSVSRKPLAFLAGIGVTALVQS
SNATALLAISFVSQGLIALAPALVIILGADVGTALMVRVLTFDLTWLSPLLIFLGVIFFL
SCKQTRAGQLGRIAIGLGLILLALELIVESATPITQTAGVKVLFSSLTGDVMLDALVGAV
FAIVSYSSLAAVLLTATLTASHVISLDVALCLVIGANLGSGILALANASAQGAAARQVAL
GSMFFKLIGCMPALPAISYLADGMEAVPLPDEERVIYFHLFYNLVRCLLLLPFVGRMAEL
CGNLVRVEPDLDPRLHPRHLDVSALDTPTLALANAARETLRIGDVIEQMLKMFQDVLRGE
RQQVREIRKLDDDVDVLYNAIKLYLAQIEKAGLHERDSRRWAEVIEMALNLEQAGDIIER
VVCDLDAHAPDGLRGFSTAGRDELNTLYEQLMNNLRLGMSVFLSSDVTSARRLRRAKHRF
RILNRRYSHAHVDRLHQQNVQSLETSSLHLGLLGDMNRLNSLFCAVAYNVLMVTEEEDEG
REESSISV