Protein Info for DZA65_RS19690 in Dickeya dianthicola ME23

Annotation: DNA mismatch repair endonuclease MutL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 642 TIGR00585: DNA mismatch repair protein MutL" amino acids 1 to 310 (310 residues), 339.7 bits, see alignment E=1.1e-105 PF02518: HATPase_c" amino acids 21 to 77 (57 residues), 31.5 bits, see alignment 4.3e-11 PF13589: HATPase_c_3" amino acids 24 to 119 (96 residues), 47.9 bits, see alignment E=2.8e-16 PF01119: DNA_mis_repair" amino acids 214 to 329 (116 residues), 137.9 bits, see alignment E=2.6e-44 PF08676: MutL_C" amino acids 466 to 592 (127 residues), 99.4 bits, see alignment E=3.1e-32

Best Hits

KEGG orthology group: K03572, DNA mismatch repair protein MutL (inferred from 91% identity to ddd:Dda3937_00436)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CJY8 at UniProt or InterPro

Protein Sequence (642 amino acids)

>DZA65_RS19690 DNA mismatch repair endonuclease MutL (Dickeya dianthicola ME23)
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIERGGAKLIRIRDNG
CGIGKAELALALARHATSKIATLDDLEAIVSLGFRGEALASISSVSRLILTSRTDAQVEA
WQAYAEGREMAVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFMHIDEVVRRIAL
ARFDVAITLHHNGKLTRQYRAVSEPAQRERRLGSICGAAFLQHALAVSWQHGDLKIHGWV
ADPTGSRQLPEMQYCYVNQRMMRDRLINHAIRQAYQDQLRDEQQPAYVLYLEVDPHQVDV
NVHPAKHEVRFHQARLVHDFIYQAVMTVLQQAASPGLTGVGDTETAATWQPENRAAAGEN
QFARPAEPAPETASAASSGSTASHPGRHARERQPAYTEAAGYQKKQGELYQQLLHTESSR
QQTVAREAPPVKNTPAARHDVTEKAVAVGDAPLESHALGLGRVLTVYPPSYALVEYQQGL
AVLSLTVAERYLRQAQLTPLEAGEGLRPQPLLIPQRLTLNPSELAVMQQQQPLLTRLGIE
VELAPPRATLRAVPLPLRQQNLQNLISDLLGYLADSHDVKPDAVAAWIAGRLGSERENWT
LAQAVQLLSDVERLCPLQVKAPPSELLYVMDIESAIRALKHE