Protein Info for DZA65_RS19390 in Dickeya dianthicola ME23

Annotation: 4-hydroxy-tetrahydrodipicolinate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00036: 4-hydroxy-tetrahydrodipicolinate reductase
  • amino acids 6 to 269 (264 residues), 360.1 bits, E=4.1e-112
• PF01113: DapB_N
  • amino acids 6 to 129 (124 residues), 145.8 bits, E=7.2e-47
• PF05173: DapB_C
  • amino acids 132 to 268 (137 residues), 153 bits, E=3.8e-49

Best Hits

Swiss-Prot: 86% identical to DAPB_KLEP3: 4-hydroxy-tetrahydrodipicolinate reductase (dapB) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: K00215, dihydrodipicolinate reductase [EC: 1.3.1.26] (inferred from 96% identity to ddd:Dda3937_01391)

MetaCyc: 85% identical to 4-hydroxy-tetrahydrodipicolinate reductase (Escherichia coli K-12 substr. MG1655)
RXN-14014 [EC: 1.17.1.8]

Predicted SEED Role

"4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8)" (EC 1.17.1.8)

MetaCyc Pathways

• aspartate superpathway (24/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• L-lysine biosynthesis III (6/7 steps found)
• L-lysine biosynthesis VI (6/7 steps found)
• L-lysine biosynthesis II (7/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.17.1.8 or 1.3.1.26

Sequence Analysis Tools

See A0A3A4CAY5 at UniProt or InterPro

Protein Sequence (273 amino acids)

>DZA65_RS19390 4-hydroxy-tetrahydrodipicolinate reductase (Dickeya dianthicola ME23)
MRDAQIRVAIAGAGGRMGRQLIQAALQMDGVALGAALEREGSSLLGSDAGELAAVGKTDI
TVQSSLEAVVDDFDVFIDFTRPEGTLRHLAFCRKHGKGMVIGTTGFDDQGKAAIQQAAAD
IGIVFAANFSVGVNVLLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIAG
ALGRDLKQCAVYTREGHTGERKPKSIGFATIRAGDIVGEHTAMFADVGERIEITHKASSR
MTFANGAVRSALWVSAHNHGLFDMRDVLELDDL