Protein Info for DZA65_RS19055 in Dickeya dianthicola ME23

Annotation: GMP reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01305: guanosine monophosphate reductase
  • amino acids 2 to 344 (343 residues), 647.9 bits, E=1.6e-199
• PF00478: IMPDH
  • amino acids 9 to 338 (330 residues), 245.1 bits, E=5.2e-77

Best Hits

Swiss-Prot: 84% identical to GUAC_EDWI9: GMP reductase (guaC) from Edwardsiella ictaluri (strain 93-146)

KEGG orthology group: K00364, GMP reductase [EC: 1.7.1.7] (inferred from 98% identity to ddd:Dda3937_02240)

MetaCyc: 82% identical to GMP reductase (Escherichia coli K-12 substr. MG1655)
GMP reductase. [EC: 1.7.1.7]

Predicted SEED Role

"GMP reductase (EC 1.7.1.7)" in subsystem Purine conversions (EC 1.7.1.7)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.7.1.7

Sequence Analysis Tools

See A0A3A4CUP2 at UniProt or InterPro

Protein Sequence (346 amino acids)

>DZA65_RS19055 GMP reductase (Dickeya dianthicola ME23)
MRIEEDIKLGFKDVLIRPKRSTLKSRADVELTREFAFLHAGCDWSGVPIIAANMDTVGTF
QMAQVLASFELLTAVHKHYSVAEWRQFVDSTPAAVLRHVMVSSGTSDGDFENMRQILALS
PDLKFICIDVANGYSEHFVNFVQKTREVFPDKVICAGNVVTGEMVEELLLSGADIIKVGI
GPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCTVPGDVAKAFGGGADFVM
LGGLLAAHEECGGDIIEEDGRKMMLFYGMSSSSAMERHVGGVAEYRAAEGKTVRLPLRGP
VEHTVRDVLGGLRSACTYVGASRLKELTKRTTFIRVVEQENRVFNG